TESK1
Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.[1][2]
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.[2]
Interactions
TESK1 has been shown to interact with YWHAB[3] and SPRY4.[4]
References
- ^ Toshima J, Ohashi K, Okano I, Nunoue K, Kishioka M, Kuma K, Miyata T, Hirai M, Baba T, Mizuno K (Feb 1996). "Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells". J Biol Chem 270 (52): 31331–7. doi:10.1074/jbc.270.52.31331. PMID 8537404.
- ^ a b "Entrez Gene: TESK1 testis-specific kinase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7016.
- ^ Toshima, J Y; Toshima J, Watanabe T, Mizuno K (Nov. 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. (United States) 276 (46): 43471–81. doi:10.1074/jbc.M104620200. ISSN 0021-9258. PMID 11555644.
- ^ Leeksma, Onno C; Van Achterberg Tanja A E, Tsumura Yoshikazu, Toshima Jiro, Eldering Eric, Kroes Wilma G M, Mellink Clemens, Spaargaren Marcel, Mizuno Kensaku, Pannekoek Hans, de Vries Carlie J M (May. 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. (Germany) 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. ISSN 0014-2956. PMID 12027893.
Further reading
- Toshima J, Tanaka T, Mizuno K (1999). "Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop.". J. Biol. Chem. 274 (17): 12171–6. doi:10.1074/jbc.274.17.12171. PMID 10207045.
- Røsok O, Pedeutour F, Ree AH, Aasheim HC (1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis.". Genomics 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.
- Toshima J, Toshima JY, Amano T, et al. (2001). "Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation.". Mol. Biol. Cell 12 (4): 1131–45. PMC 32292. PMID 11294912. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=32292.
- Toshima J, Toshima JY, Takeuchi K, et al. (2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells.". J. Biol. Chem. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.
- Toshima JY, Toshima J, Watanabe T, Mizuno K (2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1.". J. Biol. Chem. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
- Leeksma OC, Van Achterberg TA, Tsumura Y, et al. (2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1.". Eur. J. Biochem. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- LaLonde DP, Brown MC, Bouverat BP, Turner CE (2005). "Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.". J. Biol. Chem. 280 (22): 21680–8. doi:10.1074/jbc.M500752200. PMID 15817463.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.