TESK1

Testis-specific kinase 1
Identifiers
Symbols TESK1;
External IDs OMIM601782 MGI1201675 HomoloGene4577 GeneCards: TESK1 Gene
EC number 2.7.12.1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7016 21754
Ensembl ENSG00000107140 ENSMUSG00000028458
UniProt Q15569 Q499W7
RefSeq (mRNA) NM_006285 NM_011571.3
RefSeq (protein) NP_006276 NP_035701.3
Location (UCSC) Chr 9:
35.61 – 35.61 Mb
Chr 4:
43.45 – 43.46 Mb
PubMed search [1] [2]

Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.[1][2]

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.[2]

Interactions

TESK1 has been shown to interact with YWHAB[3] and SPRY4.[4]

References

  1. ^ Toshima J, Ohashi K, Okano I, Nunoue K, Kishioka M, Kuma K, Miyata T, Hirai M, Baba T, Mizuno K (Feb 1996). "Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells". J Biol Chem 270 (52): 31331–7. doi:10.1074/jbc.270.52.31331. PMID 8537404. 
  2. ^ a b "Entrez Gene: TESK1 testis-specific kinase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7016. 
  3. ^ Toshima, J Y; Toshima J, Watanabe T, Mizuno K (Nov. 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. (United States) 276 (46): 43471–81. doi:10.1074/jbc.M104620200. ISSN 0021-9258. PMID 11555644. 
  4. ^ Leeksma, Onno C; Van Achterberg Tanja A E, Tsumura Yoshikazu, Toshima Jiro, Eldering Eric, Kroes Wilma G M, Mellink Clemens, Spaargaren Marcel, Mizuno Kensaku, Pannekoek Hans, de Vries Carlie J M (May. 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. (Germany) 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. ISSN 0014-2956. PMID 12027893. 

Further reading