TERF2IP

Telomeric repeat binding factor 2, interacting protein

PDB rendering based on 1fex.

Available structures
PDB	1FEX, 3K6G

Identifiers

Symbols

TERF2IP; DRIP5; RAP1

External IDs

OMIM: 605061 MGI: 1929871 HomoloGene: 10357 GeneCards: TERF2IP Gene

Gene Ontology
Molecular function	• DNA binding • protein binding • telomeric DNA binding
Cellular component	• nuclear chromosome • chromosome, telomeric region • chromosome, telomeric region • nuclear telomere cap complex • nuclear chromosome, telomeric region • nucleus • nucleus • nucleoplasm • nucleoplasm • cytoplasm • cytoplasm • Mre11 complex
Biological process	• telomere maintenance • telomere maintenance • regulation of transcription, DNA-dependent • telomere maintenance via telomerase • regulation of double-strand break repair via homologous recombination • telomere maintenance via telomere lengthening • protection from non-homologous end joining at telomere • protection from non-homologous end joining at telomere • negative regulation of telomere maintenance • negative regulation of telomere maintenance • positive regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of DNA recombination at telomere • positive regulation of NF-kappaB transcription factor activity • protein localization to chromosome, telomeric region
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
75.68 – 75.69 Mb

Chr 8:
114.54 – 114.54 Mb

PubMed search

[1]

[2]

Telomeric repeat-binding factor 2-interacting protein 1 is a protein that in humans is encoded by the TERF2IP gene.^[1]^[2]

Interactions

TERF2IP has been shown to interact with Ku80,^[3] Rad50^[3] and TERF2.^[3]^[1]^[4]

References

^ ^a ^b Li B, Oestreich S, de Lange T (Jul 2000). "Identification of human Rap1: implications for telomere evolution". Cell 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490.
^ "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54386.
^ ^a ^b ^c O'Connor, Matthew S; Safari Amin, Liu Dan, Qin Jun, Songyang Zhou (Jul. 2004). "The human Rap1 protein complex and modulation of telomere length". J. Biol. Chem. (United States) 279 (27): 28585–91. doi:10.1074/jbc.M312913200. ISSN 0021-9258. PMID 15100233.
^ Zhu, X D; Küster B, Mann M, Petrini J H, de Lange T (Jul. 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nat. Genet. (UNITED STATES) 25 (3): 347–52. doi:10.1038/77139. ISSN 1061-4036. PMID 10888888.

Zhu XD, Küster B, Mann M, et al. (2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.". Nat. Genet. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888.
Hanaoka S, Nagadoi A, Yoshimura S, et al. (2001). "NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains.". J. Mol. Biol. 312 (1): 167–75. doi:10.1006/jmbi.2001.4924. PMID 11545594.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Loayza D, De Lange T (2003). "POT1 as a terminal transducer of TRF1 telomere length control.". Nature 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.
Li B, de Lange T (2004). "Rap1 affects the length and heterogeneity of human telomeres.". Mol. Biol. Cell 14 (12): 5060–8. doi:10.1091/mbc.E03-06-0403. PMC 284807. PMID 14565979. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=284807.
Zhu XD, Niedernhofer L, Kuster B, et al. (2004). "ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.". Mol. Cell 12 (6): 1489–98. doi:10.1016/S1097-2765(03)00478-7. PMID 14690602.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
O'Connor MS, Safari A, Liu D, et al. (2004). "The human Rap1 protein complex and modulation of telomere length.". J. Biol. Chem. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. PMID 15100233.
Liu D, Safari A, O'Connor MS, et al. (2004). "PTOP interacts with POT1 and regulates its localization to telomeres.". Nat. Cell Biol. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Ye JZ, Donigian JR, van Overbeek M, et al. (2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.". J. Biol. Chem. 279 (45): 47264–71. doi:10.1074/jbc.M409047200. PMID 15316005.
Liu D, O'Connor MS, Qin J, Songyang Z (2005). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.". J. Biol. Chem. 279 (49): 51338–42. doi:10.1074/jbc.M409293200. PMID 15383534.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842.
Antoine K, Ferbus D, Kolahgar G, et al. (2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1.". J. Cell. Biochem. 95 (4): 763–8. doi:10.1002/jcb.20487. PMID 15838871.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Wu Y, Zacal NJ, Rainbow AJ, Zhu XD (2007). "XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening.". DNA Repair (Amst.) 6 (2): 157–66. doi:10.1016/j.dnarep.2006.09.005. PMID 17055345.
Bae NS, Baumann P (2007). "A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends.". Mol. Cell 26 (3): 323–34. doi:10.1016/j.molcel.2007.03.023. PMID 17499040.

PDB gallery

1fex: SOLUTION STRUCTURE OF MYB-DOMAIN OF HUMAN RAP1

TERF2IP

Interactions

References

Further reading