TERF1

Telomeric repeat binding factor (NIMA-interacting) 1

PDB rendering based on 1ba5.
Identifiers
Symbols TERF1; FLJ41416; PIN2; TRBF1; TRF; TRF1; hTRF1-AS; t-TRF1
External IDs OMIM: 600951 MGI: 109634 HomoloGene: 7570 GeneCards: TERF1 Gene
Orthologs
Species Human Mouse
Entrez 7013 21749
Ensembl ENSG00000147601 ENSMUSG00000025925
UniProt P54274 Q7TSK8
RefSeq (mRNA) NM_003218.3 NM_009352.2
RefSeq (protein) NP_003209.2 NP_033378.1
Location (UCSC) Chr 8:
73.92 – 73.96 Mb		 Chr 1:
15.8 – 15.83 Mb
PubMed search [1] [2]

Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene.[1][2]

This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.[2]

Interactions

TERF1 has been shown to interact with SALL1,[3] MAPRE1,[4] NME1,[5] TNKS2,[6][7][8] Ataxia telangiectasia mutated,[9] TINF2,[10][11][12] TNKS,[6][8][13][14][15] PINX1[16] and Abl gene.[9]

References

  1. ^ Shen M, Haggblom C, Vogt M, Hunter T, Lu KP (Jan 1998). "Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis". Proc Natl Acad Sci U S A 94 (25): 13618–23. doi:10.1073/pnas.94.25.13618. PMC 28355. PMID 9391075. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=28355. 
  2. ^ a b "Entrez Gene: TERF1 telomeric repeat binding factor (NIMA-interacting) 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7013. 
  3. ^ Netzer, C; Rieger L, Brero A, Zhang C D, Hinzke M, Kohlhase J, Bohlander S K (Dec. 2001). "SALL1, the gene mutated in Townes-Brocks syndrome, encodes a transcriptional repressor which interacts with TRF1/PIN2 and localizes to pericentromeric heterochromatin". Hum. Mol. Genet. (England) 10 (26): 3017–24. doi:10.1093/hmg/10.26.3017. ISSN 0964-6906. PMID 11751684. 
  4. ^ Nakamura, Masafumi; Zhou X Z, Kishi Shuji, Lu K P (Mar. 2002). "Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle". FEBS Lett. (Netherlands) 514 (2-3): 193–8. doi:10.1016/S0014-5793(02)02363-3. ISSN 0014-5793. PMID 11943150. 
  5. ^ Nosaka, K; Kawahara M, Masuda M, Satomi Y, Nishino H (Feb. 1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. (UNITED STATES) 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. ISSN 0006-291X. PMID 9480811. 
  6. ^ a b Cook, Brandoch D; Dynek Jasmin N, Chang William, Shostak Grigoriy, Smith Susan (Jan. 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. (United States) 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. ISSN 0270-7306. PMC 134233. PMID 11739745. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134233. 
  7. ^ Chi, N W; Lodish H F (Dec. 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. (UNITED STATES) 275 (49): 38437–44. doi:10.1074/jbc.M007635200. ISSN 0021-9258. PMID 10988299. 
  8. ^ a b Sbodio, Juan I; Lodish Harvey F, Chi Nai-Wen (Feb. 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. (England) 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222327. 
  9. ^ a b Kishi, S; Zhou X Z, Ziv Y, Khoo C, Hill D E, Shiloh Y, Lu K P (Aug. 2001). "Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks". J. Biol. Chem. (United States) 276 (31): 29282–91. doi:10.1074/jbc.M011534200. ISSN 0021-9258. PMID 11375976. 
  10. ^ Liu, Dan; Safari Amin, O'Connor Matthew S, Chan Doug W, Laegeler Andrew, Qin Jun, Songyang Zhou (Jul. 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nat. Cell Biol. (England) 6 (7): 673–80. doi:10.1038/ncb1142. ISSN 1465-7392. PMID 15181449. 
  11. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep. 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 
  12. ^ Kim, S H; Kaminker P, Campisi J (Dec. 1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. (UNITED STATES) 23 (4): 405–12. doi:10.1038/70508. ISSN 1061-4036. PMID 10581025. 
  13. ^ Seimiya, Hiroyuki; Smith Susan (Apr. 2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J. Biol. Chem. (United States) 277 (16): 14116–26. doi:10.1074/jbc.M112266200. ISSN 0021-9258. PMID 11854288. 
  14. ^ Sbodio, Juan I; Chi Nai-Wen (Aug. 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. (United States) 277 (35): 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061. 
  15. ^ Smith, S; Giriat I, Schmitt A, de Lange T (Nov. 1998). "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres". Science (UNITED STATES) 282 (5393): 1484–7. doi:10.1126/science.282.5393.1484. ISSN 0036-8075. PMID 9822378. 
  16. ^ Zhou, X Z; Lu K P (Nov. 2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor". Cell (United States) 107 (3): 347–59. doi:10.1016/S0092-8674(01)00538-4. ISSN 0092-8674. PMID 11701125. 

Further reading