TCF3

Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

Identifiers

TCF3; E2A; ITF1; MGC129647; MGC129648; VDIR; bHLHb21

External IDs

OMIM: 147141 MGI: 98510 HomoloGene: 2408 GeneCards: TCF3 Gene

Gene Ontology
Molecular function	• DNA binding • DNA binding • DNA binding • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • protein binding • transcription factor binding • mitogen-activated protein kinase kinase kinase binding • identical protein binding • protein homodimerization activity • bHLH transcription factor binding • sequence-specific DNA binding • sequence-specific DNA binding • transcription regulatory region DNA binding • protein heterodimerization activity • protein heterodimerization activity • protein heterodimerization activity • vitamin D response element binding • E-box binding • E-box binding
Cellular component	• nuclear nucleosome • nucleus • nucleus • nucleoplasm • transcription factor complex • transcription factor complex • cytoplasm • protein complex
Biological process	• G1 phase of mitotic cell cycle • B cell lineage commitment • B cell lineage commitment • transcription, DNA-dependent • transcription, DNA-dependent • regulation of transcription, DNA-dependent • B cell differentiation • positive regulation of B cell proliferation • response to lipopolysaccharide • immunoglobulin V(D)J recombination • response to drug • muscle cell differentiation • histone H3 acetylation • histone H4 acetylation • positive regulation of neuron differentiation • positive regulation of cell cycle • positive regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • protein stabilization • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of muscle cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
1.61 – 1.65 Mb

Chr 10:
79.87 – 79.9 Mb

PubMed search

[1]

[2]

Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene.^[1]^[2]^[3] TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression.^[4]

Interactions

TCF3 has been shown to interact with ID3,^[5]^[6] LYL1,^[7] Twist transcription factor,^[8] PCAF,^[9] LMX1A,^[10] LDB1,^[11] ELK3,^[12] CBFA2T3,^[11] MyoD,^[13]^[6] EP300,^[9] CREB-binding protein,^[9] MAPKAPK3,^[14] Myogenin,^[6]^[15] TAL1^[11]^[16] and UBE2I.^[17]

References

^ "Entrez Gene: TCF3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9760.
^ Henthorn P, McCarrick-Walmsley R, Kadesch T (February 1990). "Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor". Nucleic Acids Res. 18 (3): 677. doi:10.1093/nar/18.3.677. PMC 333499. PMID 2308859. http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=2308859.
^ Kamps MP, Murre C, Sun XH, Baltimore D (February 1990). "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL". Cell 60 (4): 547–55. doi:10.1016/0092-8674(90)90658-2. PMID 1967983. http://linkinghub.elsevier.com/retrieve/pii/0092-8674(90)90658-2.
^ E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
^ Deed, R W; Jasiok M, Norton J D (Apr. 1998). "Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells". J. Biol. Chem. (UNITED STATES) 273 (14): 8278–86. doi:10.1074/jbc.273.14.8278. ISSN 0021-9258. PMID 9525934.
^ ^a ^b ^c Langlands, K; Yin X, Anand G, Prochownik E V (Aug. 1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. (UNITED STATES) 272 (32): 19785–93. doi:10.1074/jbc.272.32.19785. ISSN 0021-9258. PMID 9242638.
^ Miyamoto, A; Cui X, Naumovski L, Cleary M L (May. 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Mol. Cell. Biol. (UNITED STATES) 16 (5): 2394–401. ISSN 0270-7306. PMC 231228. PMID 8628307. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231228.
^ El Ghouzzi, V; Legeai-Mallet L, Aresta S, Benoist C, Munnich A, de Gunzburg J, Bonaventure J (Mar. 2000). "Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location". Hum. Mol. Genet. (ENGLAND) 9 (5): 813–9. doi:10.1093/hmg/9.5.813. ISSN 0964-6906. PMID 10749989.
^ ^a ^b ^c Bradney, Curtis; Hjelmeland Mark, Komatsu Yasuhiko, Yoshida Minoru, Yao Tso-Pang, Zhuang Yuan (Jan. 2003). "Regulation of E2A activities by histone acetyltransferases in B lymphocyte development". J. Biol. Chem. (United States) 278 (4): 2370–6. doi:10.1074/jbc.M211464200. ISSN 0021-9258. PMID 12435739.
^ Johnson, J D; Zhang W, Rudnick A, Rutter W J, German M S (Jul. 1997). "Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity". Mol. Cell. Biol. (UNITED STATES) 17 (7): 3488–96. ISSN 0270-7306. PMC 232202. PMID 9199284. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232202.
^ ^a ^b ^c Goardon, Nicolas; Lambert Julie A, Rodriguez Patrick, Nissaire Philippe, Herblot Sabine, Thibault Pierre, Dumenil Dominique, Strouboulis John, Romeo Paul-Henri, Hoang Trang (Jan. 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. (England) 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. ISSN 0261-4189. PMC 1383517. PMID 16407974. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1383517.
^ Maira, S M; Wurtz J M, Wasylyk B (Nov. 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. (ENGLAND) 15 (21): 5849–65. ISSN 0261-4189. PMC 452333. PMID 8918463. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452333.
^ Maleki, S J; Royer C A, Hurlburt B K (Jun. 1997). "MyoD-E12 heterodimers and MyoD-MyoD homodimers are equally stable". Biochemistry (UNITED STATES) 36 (22): 6762–7. doi:10.1021/bi970262m. ISSN 0006-2960. PMID 9184158.
^ Neufeld, B; Grosse-Wilde A, Hoffmeyer A, Jordan B W, Chen P, Dinev D, Ludwig S, Rapp U R (Jul. 2000). "Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity". J. Biol. Chem. (UNITED STATES) 275 (27): 20239–42. doi:10.1074/jbc.C901040199. ISSN 0021-9258. PMID 10781029.
^ Chakraborty, T; Martin J F, Olson E N (Sep. 1992). "Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system". J. Biol. Chem. (UNITED STATES) 267 (25): 17498–501. ISSN 0021-9258. PMID 1325437.
^ Hsu, H L; Wadman I, Baer R (Apr. 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. ISSN 0027-8424. PMC 43539. PMID 8159721. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43539.
^ Huggins, G S; Chin M T, Sibinga N E, Lee S L, Haber E, Lee M E (Oct. 1999). "Characterization of the mUBC9-binding sites required for E2A protein degradation". J. Biol. Chem. (UNITED STATES) 274 (40): 28690–6. doi:10.1074/jbc.274.40.28690. ISSN 0021-9258. PMID 10497239.

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1

(1.3) bHLH-ZIP	AP-4 · MAX · MITF · MNT · MLX · MXI1 · Myc · SREBP (1, 2)

(1.4) NF-1	NFI (A, B, C, X) · SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)

(1.5) RF-X	RFX (1, 2, 3, 4, 5, ANK)

(1.6) Basic helix-span-helix (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Zinc finger DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1

(2.3) Cys₂His₂	General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B

(3) Helix-turn-helix domains

(3.1) Homeodomain	ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2) · DLX (3, 4, 5) · EMX2 · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B) · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · VAX1 · ZEB (1, 2)

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, I1, J1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2

(3.6) TEA domain	transcriptional enhancer factor (1, 2, 3, 4)

(4) β-Scaffold factors with minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53 · TBX (1, 2, 3, 5, 19, 21, 22, Brachyury, TBR1, TBR2) · TP63

(4.4) MADS box	Mef2 (A, B, C, D) · SRF

(4.6) TATA binding proteins	TBP · TBPL1

(4.7) High-mobility group	BBX · HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4) · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4)

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) · HBP1

(0.3) Pocket domain	Rb · RBL1 · RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 · EREBP · B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma

see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

TCF3

Interactions

References

Further reading