HNF1B

HNF1 homeobox B

PDB rendering based on 2da6.
Identifiers
Symbols HNF1B; FJHN; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF2; VHNF1
External IDs OMIM: 189907 MGI: 98505 HomoloGene: 396 GeneCards: HNF1B Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6928 21410
Ensembl ENSG00000108753 ENSMUSG00000020679
UniProt P35680 Q2M4H2
RefSeq (mRNA) NM_000458.2 NM_009330.2
RefSeq (protein) NP_000449.1 NP_033356.2
Location (UCSC) Chr 17:
36.05 – 36.11 Mb		 Chr 11:
83.66 – 83.72 Mb
PubMed search [1] [2]

HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene.

TCF2 encodes transcription factor 2, a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1; depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.[1]

Contents

See also

References

  1. ^ "Entrez Gene: TCF2 transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6928. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.