TAP1
Antigen peptide transporter 1 is a protein that in humans is encoded by the TAP1 gene.[1][2]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.[3]
See also
Interactions
TAP1 has been shown to interact with Tapasin[4][5] and HLA-A.[5]
References
- ^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR et al. (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens 39 (4): 161–73. PMID 1529427.
- ^ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A 88 (22): 10094–8. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52874.
- ^ "Entrez Gene: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6890.
- ^ Raghuraman, Gayatri; Lapinski Philip Edward, Raghavan Malini (Nov. 2002). "Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes". J. Biol. Chem. (United States) 277 (44): 41786–94. doi:10.1074/jbc.M207128200. ISSN 0021-9258. PMID 12213826.
- ^ a b Paulsson, Kajsa M; Kleijmeer Monique J, Griffith Janice, Jevon Marc, Chen Shangwu, Anderson Per O, Sjogren Hans-Olov, Li Suling, Wang Ping (May. 2002). "Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum". J. Biol. Chem. (United States) 277 (21): 18266–71. doi:10.1074/jbc.M201388200. ISSN 0021-9258. PMID 11884415.
Further reading
- Townsend A, Trowsdale J (1993). "The transporters associated with antigen presentation". Semin. Cell Biol. 4 (1): 53–61. doi:10.1006/scel.1993.1007. PMID 8453065.
- Schölz C, Tampé R (2006). "The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms". J. Bioenerg. Biomembr. 37 (6): 509–15. doi:10.1007/s10863-005-9500-1. PMID 16691491.
- Beck S, Kelly A, Radley E et al. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–41. doi:10.1016/0022-2836(92)90832-5. PMID 1453454.
- Colonna M, Bresnahan M, Bahram S et al. (1992). "Allelic variants of the human putative peptide transporter involved in antigen processing". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3932–6. doi:10.1073/pnas.89.9.3932. PMC 525605. PMID 1570316. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=525605.
- Trowsdale J, Hanson I, Mockridge I et al. (1991). "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters". Nature 348 (6303): 741–4. doi:10.1038/348741a0. PMID 2259383.
- Spies T, Bresnahan M, Bahram S et al. (1991). "A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway". Nature 348 (6303): 744–7. doi:10.1038/348744a0. PMID 2259384.
- Cerundolo V, Alexander J, Anderson K et al. (1990). "Presentation of viral antigen controlled by a gene in the major histocompatibility complex". Nature 345 (6274): 449–52. doi:10.1038/345449a0. PMID 2342577.
- Szafer F, Oksenberg JR, Steinman L (1994). "New allelic polymorphisms in TAP genes". Immunogenetics 39 (5): 374. doi:10.1007/BF00189240. PMID 8168860.
- Jackson DG, Capra JD (1994). "TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11079–83. doi:10.1073/pnas.90.23.11079. PMC 47925. PMID 8248212. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47925.
- Glynne R, Kerr LA, Mockridge I et al. (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing". Eur. J. Immunol. 23 (4): 860–6. doi:10.1002/eji.1830230414. PMID 8458375.
- Beck S, Abdulla S, Alderton RP et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
- Chen HL, Gabrilovich D, Tampé R et al. (1996). "A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer". Nat. Genet. 13 (2): 210–3. doi:10.1038/ng0696-210. PMID 8640228.
- Ahn K, Meyer TH, Uebel S et al. (1996). "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47". EMBO J. 15 (13): 3247–55. PMC 451885. PMID 8670825. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=451885.
- Lewis JW, Neisig A, Neefjes J, Elliott T (1997). "Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP". Curr. Biol. 6 (7): 873–83. doi:10.1016/S0960-9822(02)00611-5. PMID 8805302.
- Nijenhuis M, Hämmerling GJ (1997). "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site". J. Immunol. 157 (12): 5467–77. PMID 8955196.
- Gobin SJ, Wilson L, Keijsers V, Van den Elsen PJ (1997). "Antigen processing and presentation by human trophoblast-derived cell lines". J. Immunol. 158 (8): 3587–92. PMID 9103419.
- Ahn K, Gruhler A, Galocha B et al. (1997). "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP". Immunity 6 (5): 613–21. doi:10.1016/S1074-7613(00)80349-0. PMID 9175839.
|
PDB gallery
|
|
|
|
1jj7: Crystal Structure of the C-terminal ATPase domain of human TAP1
|
|
|
|
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
|
|
| A |
|
|
| B |
|
|
| C |
|
|
| D |
|
|
| E |
|
|
| F |
|
|
| G |
|
|
|
see also ABC transporter disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr
|
|