TAOK3

TAO kinase 3

Identifiers

TAOK3; DKFZp666H245; DPK; FLJ31808; JIK; MAP3K18

External IDs

MGI: 3041177 HomoloGene: 83279 GeneCards: TAOK3 Gene

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • protein serine/threonine kinase activity • protein kinase inhibitor activity • ATP binding • transferase activity
Cellular component	• cytoplasm • mitochondrion • plasma membrane
Biological process	• MAPKKK cascade • protein phosphorylation • negative regulation of JNK cascade • positive regulation of JNK cascade • protein autophosphorylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
118.59 – 118.81 Mb

Chr 5:
117.57 – 117.73 Mb

PubMed search

[1]

[2]

Serine/threonine-protein kinase TAO3 is an enzyme that in humans is encoded by the TAOK3 gene.^[1]^[2]^[3]

References

^ Tassi E, Biesova Z, Di Fiore PP, Gutkind JS, Wong WT (Dec 1999). "Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor". J Biol Chem 274 (47): 33287–95. doi:10.1074/jbc.274.47.33287. PMID 10559204.
^ Zhang W, Chen T, Wan T, He L, Li N, Yuan Z, Cao X (Sep 2000). "Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways". Biochem Biophys Res Commun 274 (3): 872–9. doi:10.1006/bbrc.2000.3244. PMID 10924369.
^ "Entrez Gene: TAOK3 TAO kinase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51347.

Yoneda T, Imaizumi K, Oono K, et al. (2001). "Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.". J. Biol. Chem. 276 (17): 13935–40. doi:10.1074/jbc.M010677200. PMID 11278723.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Yustein JT, Xia L, Kahlenburg JM, et al. (2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.". Oncogene 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID 13679851.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.". Br. J. Dermatol. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.

TAOK3

References

Further reading