TAOK2

TAO kinase 2

PDB rendering based on 1u5q.

Available structures
PDB	1u5q, 1u5r, 2gcd

Identifiers

Symbols

TAOK2; KIAA0881; MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2

External IDs

OMIM: 613199 HomoloGene: 74531 GeneCards: TAOK2 Gene

EC number

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • protein serine/threonine kinase activity • ATP binding
Cellular component	• nucleus • nucleolus • cytoplasm • cytoskeleton • membrane • integral to membrane • cytoplasmic membrane-bounded vesicle • dendrite • cytoplasmic vesicle membrane • cell projection
Biological process	• activation of MAPKK activity • regulation of cell growth • protein targeting to membrane • apoptosis • response to stress • regulation of cell shape • cell migration • actin cytoskeleton organization • positive regulation of JNK cascade • focal adhesion assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_004783.2

n/a

RefSeq (protein)

NP_004774.1

n/a

Location (UCSC)

Chr 16:
29.99 – 30 Mb

n/a

PubMed search

[1]

n/a

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.^[1]^[2]^[3]

Interactions

TAOK2 has been shown to interact with MAP2K6^[4] and MAP2K3.^[4]

References

^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Hutchison M, Berman KS, Cobb MH (Dec 1998). "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades". J Biol Chem 273 (44): 28625–32. doi:10.1074/jbc.273.44.28625. PMID 9786855.
^ "Entrez Gene: TAOK2 TAO kinase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9344.
^ ^a ^b Chen, Z; Cobb M H (May. 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. (United States) 276 (19): 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118.

Chen Z, Hutchison M, Cobb MH (1999). "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.". J. Biol. Chem. 274 (40): 28803–7. doi:10.1074/jbc.274.40.28803. PMID 10497253.
Moore TM, Garg R, Johnson C, et al. (2000). "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization.". J. Biol. Chem. 275 (6): 4311–22. doi:10.1074/jbc.275.6.4311. PMID 10660600.
Chen Z, Cobb MH (2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.". J. Biol. Chem. 276 (19): 16070–5. doi:10.1074/jbc.M100681200. PMID 11279118.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Mitsopoulos C, Zihni C, Garg R, et al. (2003). "The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.". J. Biol. Chem. 278 (20): 18085–91. doi:10.1074/jbc.M213064200. PMID 12639963.
Chen Z, Raman M, Chen L, et al. (2003). "TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.". J. Biol. Chem. 278 (25): 22278–83. doi:10.1074/jbc.M301173200. PMID 12665513.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Yustein JT, Xia L, Kahlenburg JM, et al. (2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.". Oncogene 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID 13679851.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Huangfu WC, Omori E, Akira S, et al. (2006). "Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.". J. Biol. Chem. 281 (39): 28802–10. doi:10.1074/jbc.M603627200. PMC 1797068. PMID 16893890. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1797068.
Zihni C, Mitsopoulos C, Tavares IA, et al. (2007). "Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing.". J. Biol. Chem. 282 (9): 6484–93. doi:10.1074/jbc.M608336200. PMID 17158878.

PDB gallery

1u5q: Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K

1u5r: Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K

2gcd: TAO2 kinase domain-staurosporine structure

TAOK2

Interactions

References

Further reading