TAF2

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
Identifiers
Symbols TAF2; CIF150; TAF2B; TAFII150
External IDs OMIM: 604912 MGI: 2443028 HomoloGene: 31137 GeneCards: TAF2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6873 319944
Ensembl ENSG00000064313 ENSMUSG00000037343
UniProt Q6P1X5 Q8C176
RefSeq (mRNA) NM_003184 NM_001081288.1
RefSeq (protein) NP_003175 NP_001074757.1
Location (UCSC) Chr 8:
120.74 – 120.85 Mb		 Chr 15:
54.85 – 54.9 Mb
PubMed search [1] [2]

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.[1][2][3]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.[3]

References

  1. ^ Martinez E, Ge H, Tao Y, Yuan CX, Palhan V, Roeder RG (Nov 1998). "Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex". Mol Cell Biol 18 (11): 6571–83. PMC 109242. PMID 9774672. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109242. 
  2. ^ Kaufmann J, Ahrens K, Koop R, Smale ST, Muller R (Jan 1998). "CIF150, a human cofactor for transcription factor IID-dependent initiator function". Mol Cell Biol 18 (1): 233–9. PMC 121482. PMID 9418870. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=121482. 
  3. ^ a b "Entrez Gene: TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6873. 

Further reading

External links