TAF11

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa

PDB rendering based on 1bh8.
Identifiers
Symbols TAF11; MGC:15243; TAF2I; TAFII28
External IDs OMIM: 600772 MGI: 1916026 HomoloGene: 55918 GeneCards: TAF11 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6882 68776
Ensembl ENSG00000064995 ENSMUSG00000024218
UniProt Q15544 Q99JX1
RefSeq (mRNA) NM_005643 NM_026836.2
RefSeq (protein) NP_005634 NP_081112.1
Location (UCSC) Chr 6:
34.85 – 34.86 Mb		 Chr 17:
28.04 – 28.05 Mb
PubMed search [1] [2]

Transcription initiation factor TFIID subunit 11 is a protein that in humans is encoded by the TAF11 gene.[1][2][3]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure.[3]

Interactions

TAF11 has been shown to interact with TAF15,[4] TAF13,[1][5] TATA binding protein,[6][1][7] GTF2F1,[8] POLR2A[8] and Transcription Factor II B.[8]

References

  1. ^ a b c Mengus G, May M, Jacq X, Staub A, Tora L, Chambon P, Davidson I (May 1995). "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID". EMBO J 14 (7): 1520–31. PMC 398239. PMID 7729427. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=398239. 
  2. ^ Kuzuhara T, Horikoshi M (Nov 1996). "Isolation and characterization of a cDNA encoding a human TFIID subunit containing a variety of putative structural motifs including direct repeats". Biol Pharm Bull 19 (1): 122–6. PMID 8820923. 
  3. ^ a b "Entrez Gene: TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6882. 
  4. ^ Bertolotti, A; Melot T, Acker J, Vigneron M, Delattre O, Tora L (Mar. 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. (UNITED STATES) 18 (3): 1489–97. ISSN 0270-7306. PMC 108863. PMID 9488465. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108863. 
  5. ^ Birck, C; Poch O, Romier C, Ruff M, Mengus G, Lavigne A C, Davidson I, Moras D (Jul. 1998). "Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family". Cell (UNITED STATES) 94 (2): 239–49. doi:10.1016/S0092-8674(00)81423-3. ISSN 0092-8674. PMID 9695952. 
  6. ^ Bellorini, M; Lee D K, Dantonel J C, Zemzoumi K, Roeder R G, Tora L, Mantovani R (Jun. 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. (ENGLAND) 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. ISSN 0305-1048. PMC 146709. PMID 9153318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146709. 
  7. ^ May, M; Mengus G, Lavigne A C, Chambon P, Davidson I (Jun. 1996). "Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors". EMBO J. (ENGLAND) 15 (12): 3093–104. ISSN 0261-4189. PMC 450252. PMID 8670810. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=450252. 
  8. ^ a b c Scully, R; Anderson S F, Chao D M, Wei W, Ye L, Young R A, Livingston D M, Parvin J D (May. 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. ISSN 0027-8424. PMC 20825. PMID 9159119. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20825. 

Further reading