TAF10

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
Identifiers
Symbols TAF10; TAF2A; TAF2H; TAFII30
External IDs OMIM: 600475 HomoloGene: 86923 GeneCards: TAF10 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6881 24075
Ensembl ENSG00000166337 ENSMUSG00000043866
UniProt Q12962 n/a
RefSeq (mRNA) NM_006284 NM_020024.3
RefSeq (protein) NP_006275 NP_064408.2
Location (UCSC) Chr 11:
6.63 – 6.63 Mb		 Chr 7:
112.89 – 112.89 Mb
PubMed search [1] [2]

Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the TAF10 gene.[1][2]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs.[2]

Interactions

TAF10 has been shown to interact with TAF9,[3] Transcription initiation protein SPT3 homolog,[4][3] TAF13[5] and TATA binding protein.[6][7]

References

  1. ^ Jacq X, Brou C, Lutz Y, Davidson I, Chambon P, Tora L (Nov 1994). "Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor". Cell 79 (1): 107–17. doi:10.1016/0092-8674(94)90404-9. PMID 7923369. 
  2. ^ a b "Entrez Gene: TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6881. 
  3. ^ a b Martinez, E; Palhan V B, Tjernberg A, Lymar E S, Gamper A M, Kundu T K, Chait B T, Roeder R G (Oct. 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. (United States) 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856. PMID 11564863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99856. 
  4. ^ Brand, M; Moggs J G, Oulad-Abdelghani M, Lejeune F, Dilworth F J, Stevenin J, Almouzni G, Tora L (Jun. 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. (England) 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. ISSN 0261-4189. PMC 150203. PMID 11406595. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150203. 
  5. ^ Mengus, G; May M, Jacq X, Staub A, Tora L, Chambon P, Davidson I (Apr. 1995). "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID". EMBO J. (ENGLAND) 14 (7): 1520–31. ISSN 0261-4189. PMC 398239. PMID 7729427. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=398239. 
  6. ^ Bellorini, M; Lee D K, Dantonel J C, Zemzoumi K, Roeder R G, Tora L, Mantovani R (Jun. 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. (ENGLAND) 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. ISSN 0305-1048. PMC 146709. PMID 9153318. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146709. 
  7. ^ Ruppert, S; Wang E H, Tjian R (Mar. 1993). "Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation". Nature (ENGLAND) 362 (6416): 175–9. doi:10.1038/362175a0. ISSN 0028-0836. PMID 7680771. 

Further reading