TADA2L
Transcriptional adapter 2-alpha is a protein that in humans is encoded by the TADA2A gene.[1][2]
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.[2]
Interactions
TADA2L has been shown to interact with GCN5L2,[3][4] TADA3L[5][6] and Myc.[7]
References
- ^ Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL (Feb 1996). "Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5". Mol Cell Biol 16 (2): 593–602. PMC 231038. PMID 8552087. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231038.
- ^ a b "Entrez Gene: TADA2L transcriptional adaptor 2 (ADA2 homolog, yeast)-like". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6871.
- ^ Barlev, N A; Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman J L, Berger S L (Mar. 1998). "Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex". Mol. Cell. Biol. (UNITED STATES) 18 (3): 1349–58. ISSN 0270-7306. PMC 108848. PMID 9488450. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108848.
- ^ Wang, L; Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis C D, Berger S L (Jan. 1997). "Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation". Mol. Cell. Biol. (UNITED STATES) 17 (1): 519–27. ISSN 0270-7306. PMC 231776. PMID 8972232. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231776.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ^ Wang, T; Kobayashi T, Takimoto R, Denes A E, Snyder E L, el-Deiry W S, Brachmann R K (Nov. 2001). "hADA3 is required for p53 activity". EMBO J. (England) 20 (22): 6404–13. doi:10.1093/emboj/20.22.6404. ISSN 0261-4189. PMC 125723. PMID 11707411. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125723.
- ^ Liu, Xiaohui; Tesfai Jerusalem, Evrard Yvonne A, Dent Sharon Y R, Martinez Ernest (May. 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". J. Biol. Chem. (United States) 278 (22): 20405–12. doi:10.1074/jbc.M211795200. ISSN 0021-9258. PMID 12660246.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Wang L, Mizzen C, Ying C et al. (1997). "Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation". Mol. Cell. Biol. 17 (1): 519–27. PMC 231776. PMID 8972232. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231776.
- Carter KC, Wang L, Shell BK et al. (1997). "The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern". Genomics 40 (3): 497–500. doi:10.1006/geno.1996.4605. PMID 9073520.
- Henriksson A, Almlöf T, Ford J et al. (1997). "Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor". Mol. Cell. Biol. 17 (6): 3065–73. PMC 232159. PMID 9154805. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232159.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Ogryzko VV, Kotani T, Zhang X et al. (1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425.
- Vassilev A, Yamauchi J, Kotani T et al. (1999). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Mol. Cell 2 (6): 869–75. doi:10.1016/S1097-2765(00)80301-9. PMID 9885574.
- Wang T, Kobayashi T, Takimoto R et al. (2002). "hADA3 is required for p53 activity". EMBO J. 20 (22): 6404–13. doi:10.1093/emboj/20.22.6404. PMC 125723. PMID 11707411. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125723.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Barlev NA, Emelyanov AV, Castagnino P et al. (2003). "A Novel Human Ada2 Homologue Functions with Gcn5 or Brg1 To Coactivate Transcription". Mol. Cell. Biol. 23 (19): 6944–57. doi:10.1128/MCB.23.19.6944-6957.2003. PMC 193946. PMID 12972612. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193946.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Qian C, Zhang Q, Li S et al. (2006). "Structure and chromosomal DNA binding of the SWIRM domain". Nat. Struct. Mol. Biol. 12 (12): 1078–85. doi:10.1038/nsmb1022. PMID 16299514.
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PDB gallery
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1x41: Solution structure of the Myb-like DNA binding domain of human Transcriptional adaptor 2-like, isoform B
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2aqe: Structural and functional analysis of ada2 alpha swirm domain
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2aqf: Structural and functional analysis of ADA2 alpha swirm domain
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2cuj: Solution structure of SWIRM domain of mouse transcriptional adaptor 2-like
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