Transcatheter arterial chemoembolization

This article is about a medical procedure. See also Tumor Necrosis Factor Alpha Converting Enzyme

Transcatheter arterial chemoembolization / Transarterial Chemoembolization (TACE) is a minimally invasive medical procedure to restrict a tumor's blood supply.

TACE has been used extensively to delay the progression of hepatocellular carcinoma (HCC), a type of liver cancer. With continuing TACE, the life span for a patient with unresectable HCC could reasonably be extended for 1–2 years, although the exact benefit would depend heavily on the patient's medical condition (see Child-Pugh score).

Procedure

TACE is an interventional radiology procedure. The procedure involves gaining percutaneous access to the hepatic artery, usually by puncturing the common femoral artery in the right groin and passing a catheter through the abdominal aorta, through the celiac trunk and common hepatic artery, into the proper hepatic artery (which supplies the liver).

The interventional radiologist then performs an arteriogram to identify the branches of the hepatic artery supplying the tumor(s) and threads smaller catheters into these branches. This position is called a superselective position. This is done to maximize the amount of the chemotherapeutic dose that is directed to the tumor and minimise the amount of the chemotherapeutic agent that could damage the normal liver tissue.

When a blood vessel supplying tumor has been selected, alternating aliquots of the chemotherapy dose and of embolic particles, or particles containing the chemotherapy agent, are injected through the catheter. The total chemotherapeutic dose may be given in one vessel's distribution, or it may be divided among several vessels supplying the tumor(s).

TACE derives its beneficial effect by two methods. Since most tumors are supplied by the hepatic artery, arterial embolization interrupts their blood supply and postpones growth until replaced by neovascularity. Secondly, focused administration of chemotherapy allows a higher dose to the tissue while simultaneously reducing systemic exposure, which is typically the dose limiting factor. This effect is potentiated by the fact that the chemotherapeutic drug is not washed out from the tumor bed after embolization. This way, in contrary with systemic chemotherapy, the therapic effect is focused in the liver, diminishing the systemic side effects of the agents.

Complications

As with any interventional procedure, there is a small risk of hemorrhage and/or damage to blood vessels. Pseudoaneurysm can develop due to the puncture in the femoral artery. During this procedure contrast media is utilized, people may develop allergy to it. Also this contrast media can use Hyperthyroidism.

The goal of the procedure is to kill tumor. The resulting necrotic material releases cytokines and other inflammatory chemicals into the blood stream, and patients are routinely kept in a hospital for one to several days following the procedure.

A concerning complication of TACE is the development of an abscess within the necrotic tissue. This is a potentially fatal event, although percutanous drainage can take place in order to prevent the septicaemia and sepsis.