TAC3

Tachykinin 3

Identifiers

TAC3; NKB; NKNB; PRO1155; ZNEUROK1

External IDs

OMIM: 162330 MGI: 98476 HomoloGene: 7560 GeneCards: TAC3 Gene

Gene Ontology
Molecular function	• receptor binding
Cellular component	• extracellular region • extracellular region • extracellular space • soluble fraction
Biological process	• tachykinin receptor signaling pathway • neuropeptide signaling pathway • female pregnancy • response to morphine • positive regulation of blood pressure
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
57.4 – 57.42 Mb

Chr 10:
127.16 – 127.17 Mb

PubMed search

[1]

[2]

Tachykinin-3 is a protein that in humans is encoded by the TAC3 gene.^[1]^[2]^[3]

References

^ Bonner TI, Affolter HU, Young AC, Young WS 3rd (Jan 1988). "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B". Brain Res 388 (3): 243–9. PMID 3479225.
^ Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ (Jul 2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia". Nature 405 (6788): 797–800. doi:10.1038/35015579. PMID 10866201.
^ "Entrez Gene: TAC3 tachykinin 3 (neuromedin K, neurokinin beta)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6866.

Page NM, Woods RJ, Lowry PJ (2001). "A regulatory role for neurokinin B in placental physiology and pre-eclampsia.". Regul. Pept. 98 (3): 97–104. doi:10.1016/S0167-0115(00)00239-1. PMID 11231038.
Rance NE, Young WS (1991). "Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women.". Endocrinology 128 (5): 2239–47. doi:10.1210/endo-128-5-2239. PMID 1708331.
Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor.". J. Biol. Chem. 269 (44): 27269–74. PMID 7961636.
Tian Y, Wu LH, Oxender DL, Chung FZ (1996). "The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity.". J. Biol. Chem. 271 (34): 20250–7. doi:10.1074/jbc.271.34.20250. PMID 8702757.
Krause JE, Staveteig PT, Mentzer JN et al. (1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds 3Hsenktide and 125I-MePhe7neurokinin B, and is responsive to tachykinin peptide agonists". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 310–5. doi:10.1073/pnas.94.1.310. PMC 19326. PMID 8990205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19326.
Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis". Neuropeptides 32 (3): 215–23. doi:10.1016/S0143-4179(98)90040-3. PMID 10189055.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Brownbill P, Bell NJ, Woods RJ et al. (2003). "Neurokinin B is a paracrine vasodilator in the human fetal placental circulation". J. Clin. Endocrinol. Metab. 88 (5): 2164–70. doi:10.1210/jc.2002-021727. PMID 12727971.
Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Schlembach D, Scalera F, Fischer T et al. (2003). "Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women". Am. J. Obstet. Gynecol. 189 (5): 1418–22. doi:10.1067/S0002-9378(03)00775-0. PMID 14634580.
Laliberte C, DiMarzo L, Morrish DW, Kaufman S (2004). "Neurokinin B causes concentration-dependent relaxation of isolated human placental resistance vessels". Regul. Pept. 117 (2): 123–6. doi:10.1016/j.regpep.2003.10.032. PMID 14700748.
Pal S, Nemeth MJ, Bodine D et al. (2004). "Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1". J. Biol. Chem. 279 (30): 31348–56. doi:10.1074/jbc.M403475200. PMID 15123623.
Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM (2005). "Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles". J. Biomol. Struct. Dyn. 22 (2): 137–48. PMID 15317475.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Page NM, Dakour J, Morrish DW (2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia". Mol. Hum. Reprod. 12 (7): 427–33. doi:10.1093/molehr/gal025. PMID 16709596.

TAC3

See also

References

Further reading