| Systematic (IUPAC) name | |
|---|---|
| 4-amino-N-pyridin-2-ylbenzenesulfonamide | |
| Clinical data | |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| MedlinePlus | a682204 |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 000144-83-2 |
| ATC code | J01EB04 QJ01EQ04 |
| PubChem | CID 5336 |
| DrugBank | DB00891 |
| ChemSpider | 5145 |
| UNII | Y5V2N1KE8U |
| KEGG | D02434 |
| ChEBI | CHEBI:132842 |
| ChEMBL | CHEMBL700 |
| Chemical data | |
| Formula | C11H11N3O2S |
| Mol. mass | 249.29 g/mol |
| SMILES | eMolecules & PubChem |
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Sulfapyridine, original UK spelling Sulphapyridine, is a sulfonamide antibacterial. At one time it was commonly referred to as M&B.
Sulfapyridine is not prescribed for treatment in humans any more. However, it may be used to treat Linear IgA Disease. It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage.
Discovered by May & Baker Ltd and logged in their Test Book on 2 November 1937 under Code No M&B693.[1] Successfully used to treat Winston Churchill's bacterial pneumonia in 1942. In a subsequent radio broadcast he said "This admirable M&B from which I did not suffer any inconvenience, was used at the earliest moment and, after a week's fever, the intruders were repulsed." In 1944 M&B693 also saved Nero, the Royal Circus lion, from pneumonia.[Glasgow Evening News January 1944.]
The drug sulfasalazine is structurally one molecule of mesalamine linked to one molecule of Sulfapyridine with an azo bond.
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