Sulfadimidine

Sulfamethazine
Systematic (IUPAC) name
4-amino-N-(4,6-dimethylpyrimidin-2-yl)
benzenesulfonamide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 57-68-1 Y
ATC code J01EB03 QJ01EQ03 QP51AG01
PubChem CID 5327
DrugBank DB01582
ChemSpider 5136 Y
UNII 48U51W007F Y
KEGG D02436 Y
ChEBI CHEBI:102265 N
ChEMBL CHEMBL446 Y
Chemical data
Formula C12H14N4O2S 
Mol. mass 278.33 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Sulfadimidine or sulfamethazine,[1] is a sulfonamide antibacterial.

There are non-standardizeda abbreviations for it as "sulfadimidine" (abbreviated SDI[2][3] and more commonly but less reliablyb SDD[4][5]) and as "sulfamethazine" (abbreviated SMT[6][7] and more commonly but less reliablyc SMZ[8][9]). Other names include sulfadimerazine, sulfadimezine, and sulphadimethylpyrimidine.[1]

Notes

References

  1. ^ a b "Sulfadimidine" (in French). Banque de données automatisée sur les médicaments. 15 November 1999. http://www.biam2.org/www/Sub3321.html. Retrieved 14 September 2009. 
  2. ^ Romváry, A; Simon, F (1992). "Sulfonamide residues in eggs". Acta veterinaria Hungarica 40 (1–2): 99–106. ISSN 0236-6290. PMID 1476095. 
  3. ^ Reddy; Jain, S. K.; Uppal, R. P. (1988). "Pharmacokinetic studies of sulphonamides in poultry". Indian Journal of Animal Sciences. http://www.cababstractsplus.org/abstracts/Abstract.aspx?AcNo=19892292426. 
  4. ^ Kamakura, K; Hasegawa, M; Koiguchi, S; Miyata, M; Okamoto, K; Narita, M; Hirahara, Y; Yamana, T et al. (1993). "Studies on the identification of sulfadimidine in pork by high performance liquid chromatography with photodiode array detector and gas chromatograph-mass spectrometry". Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences (111): 61–5. ISSN 0077-4715. PMID 7920569. 
  5. ^ Garg, SK; Ghosh, SS; Mathur, VS (Jan 1986). "Comparative pharmacokinetic study of four different sulfonamides in combination with trimethoprim in human volunteers". International journal of clinical pharmacology, therapy, and toxicology 24 (1): 23–5. ISSN 0174-4879. PMID 3485584. 
  6. ^ Peña, MS; Salinas, F; Mahedero, MC; Aaron, JJ (Feb 1994). "Solvent effect on the determination of sulfamethazine by room-temperature photochemically induced fluorescence". Talanta 41 (2): 233–6. doi:10.1016/0039-9140(94)80113-4. ISSN 0039-9140. PMID 18965913. 
  7. ^ Kaniou, S; Pitarakis, K; Barlagianni, I; Poulios, I (Jul 2005). "Photocatalytic oxidation of sulfamethazine". Chemosphere 60 (3): 372–80. doi:10.1016/j.chemosphere.2004.11.069. ISSN 0045-6535. PMID 15924956. 
  8. ^ Calvo, R; Sarabia, S; Carlos, R; Du Souich, P (Mar 1987). "Sulfamethazine absorption and disposition: effect of surgical procedures for gastroduodenal ulcers". Biopharmaceutics & drug disposition 8 (2): 115–24. doi:10.1002/bdd.2510080203. ISSN 0142-2782. PMID 3593892. 
  9. ^ De Liguoro, M; Fioretto, B; Poltronieri, C; Gallina, G (Jun 2009). "The toxicity of sulfamethazine to Daphnia magna and its additivity to other veterinary sulfonamides and trimethoprim". Chemosphere 75 (11): 1519–24. doi:10.1016/j.chemosphere.2009.02.002. ISSN 0045-6535. PMID 19269673. 
  10. ^ http://chem.sis.nlm.nih.gov/chemidplus/ProxyServlet?objectHandle=Search&actionHandle=getAll3DMViewFiles&nextPage=jsp%2Fcommon%2FChemFull.jsp%3FcalledFrom%3Dlite&chemid=000149451&formatType=_3D

Further reading

Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)
Other/ungrouped
Combinations
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)
Related (DG)
Anaerobic DNA
inhibitors
Nitro- imidazole derivatives
Nitrofuran derivatives
RNA synthesis

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)