STAT1

Signal transducer and activator of transcription 1, 91kDa

STAT1 bound to DNA

Available structures
PDB	1BF5, 1YVL, 2KA6

Identifiers

Symbols

STAT1; DKFZp686B04100; ISGF-3; STAT91

External IDs

OMIM: 600555 MGI: 103063 HomoloGene: 21428 GeneCards: STAT1 Gene

Gene Ontology
Molecular function	• RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity • DNA binding • sequence-specific DNA binding transcription factor activity • signal transducer activity • calcium ion binding • protein binding • sequence-specific DNA binding
Cellular component	• nucleus • nucleoplasm • nucleoplasm • nucleolus • nucleolus • cytoplasm • cytosol • cytosol • axon • dendrite
Biological process	• regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • induction of apoptosis • activation of caspase activity • signal transduction • I-kappaB kinase/NF-kappaB cascade • JAK-STAT cascade • tyrosine phosphorylation of STAT protein • response to nutrient • blood circulation • response to mechanical stimulus • response to virus • response to bacterium • response to organic cyclic compound • cytokine-mediated signaling pathway • lipopolysaccharide-mediated signaling pathway • response to lipopolysaccharide • cellular response to insulin stimulus • response to cytokine stimulus • response to drug • response to hydrogen peroxide • response to exogenous dsRNA • response to peptide hormone stimulus • interspecies interaction between organisms • positive regulation of smooth muscle cell proliferation • response to cAMP • interferon-gamma-mediated signaling pathway • interferon-gamma-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
191.83 – 191.89 Mb

Chr 1:
52.18 – 52.22 Mb

PubMed search

[1]

[2]

STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon Stimulated Response Element) promoter element.^[1] In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).

Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.^[2]

1 Interactions
2 References
3 Further reading
4 External links

Interactions

STAT1 has been shown to interact with Protein kinase R,^[3]^[4] Src,^[5]^[6] IRF1,^[7] STAT3,^[8]^[9]^[10] MCM5,^[11]^[12] STAT2,^[13]^[14]^[15] CD117,^[16] Fanconi anemia, complementation group C,^[17]^[18]^[19] CREB-binding protein,^[20] Interleukin 27 receptor, alpha subunit,^[21] PIAS1,^[22] BRCA1,^[23] Epidermal growth factor receptor,^[5]^[10] PTK2,^[24] Mammalian target of rapamycin,^[25] IFNAR2,^[26]^[27] PRKCD,^[25] TRADD,^[28] C-jun,^[29] Calcitriol receptor,^[30] ISGF3G^[31] and GNB2L1.^[32]^[27]

References

^ Michael G. Katze, Yupeng He & Michael Gale et al. (2002). "Viruses and interferon: a fight for supremacy". Nature Reviews Immunology 2 (9): 675–87. doi:10.1038/nri888. PMID 12209136.
^ Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG. (2007). "Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR". Cancer Genomics Proteomics. 4 (2): 93–7. PMID 17804871.
^ Wong, A H; Tam N W, Yang Y L, Cuddihy A R, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas A E (Mar. 1997). "Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways". EMBO J. (ENGLAND) 16 (6): 1291–304. doi:10.1093/emboj/16.6.1291. ISSN 0261-4189. PMC 1169727. PMID 9135145. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169727.
^ Wong, A H; Durbin J E, Li S, Dever T E, Decker T, Koromilas A E (Apr. 2001). "Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR". J. Biol. Chem. (United States) 276 (17): 13727–37. doi:10.1074/jbc.M011240200. ISSN 0021-9258. PMID 11278865.
^ ^a ^b Olayioye, M A; Beuvink I, Horsch K, Daly J M, Hynes N E (Jun. 1999). "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". J. Biol. Chem. (UNITED STATES) 274 (24): 17209–18. doi:10.1074/jbc.274.24.17209. ISSN 0021-9258. PMID 10358079.
^ Cirri, P; Chiarugi P, Marra F, Raugei G, Camici G, Manao G, Ramponi G (Oct. 1997). "c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells". Biochem. Biophys. Res. Commun. (UNITED STATES) 239 (2): 493–7. doi:10.1006/bbrc.1997.7493. ISSN 0006-291X. PMID 9344858.
^ Chatterjee-Kishore, M; van Den Akker F, Stark G R (Jul. 2000). "Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1". J. Biol. Chem. (UNITED STATES) 275 (27): 20406–11. doi:10.1074/jbc.M001861200. ISSN 0021-9258. PMID 10764778.
^ Gunaje, J J; Bhat G J (Oct. 2001). "Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin". Biochem. Biophys. Res. Commun. (United States) 288 (1): 252–7. doi:10.1006/bbrc.2001.5759. ISSN 0006-291X. PMID 11594781.
^ Spiekermann, K; Biethahn S, Wilde S, Hiddemann W, Alves F (Aug. 2001). "Constitutive activation of STAT transcription factors in acute myelogenous leukemia". Eur. J. Haematol. (Denmark) 67 (2): 63–71. ISSN 0902-4441. PMID 11722592.
^ ^a ^b Xia, Ling; Wang Lijuan, Chung Alicia S, Ivanov Stanimir S, Ling Mike Y, Dragoi Ana M, Platt Adam, Gilmer Tona M, Fu Xin-Yuan, Chin Y Eugene (Aug. 2002). "Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation". J. Biol. Chem. (United States) 277 (34): 30716–23. doi:10.1074/jbc.M202823200. ISSN 0021-9258. PMID 12070153.
^ Zhang, J J; Zhao Y, Chait B T, Lathem W W, Ritzi M, Knippers R, Darnell J E (Dec. 1998). "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation". EMBO J. (ENGLAND) 17 (23): 6963–71. doi:10.1093/emboj/17.23.6963. ISSN 0261-4189. PMC 1171044. PMID 9843502. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171044.
^ DaFonseca, C J; Shu F, Zhang J J (Mar. 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. doi:10.1073/pnas.061487598. ISSN 0027-8424. PMC 30602. PMID 11248027. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=30602.
^ Li, X; Leung S, Qureshi S, Darnell J E, Stark G R (Mar. 1996). "Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha". J. Biol. Chem. (UNITED STATES) 271 (10): 5790–4. doi:10.1074/jbc.271.10.5790. ISSN 0021-9258. PMID 8621447.
^ Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C (Aug. 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". J. Biol. Chem. (UNITED STATES) 274 (34): 24059–65. doi:10.1074/jbc.274.34.24059. ISSN 0021-9258. PMID 10446176.
^ Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka (Aug. 2002). "Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5". J. Biol. Chem. (United States) 277 (33): 30072–8. doi:10.1074/jbc.M202943200. ISSN 0021-9258. PMID 12048190.
^ Deberry, C; Mou S, Linnekin D (Oct. 1997). "Stat1 associates with c-kit and is activated in response to stem cell factor". Biochem. J. (ENGLAND) 327 ( Pt 1): 73–80. ISSN 0264-6021. PMC 1218765. PMID 9355737. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218765.
^ Pang, Q; Fagerlie S, Christianson T A, Keeble W, Faulkner G, Diaz J, Rathbun R K, Bagby G C (Jul. 2000). "The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4724–35. doi:10.1128/MCB.20.13.4724-4735.2000. ISSN 0270-7306. PMC 85895. PMID 10848598. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85895.
^ Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J (Oct. 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. (United States) 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. ISSN 0014-4827. PMID 14499622.
^ Pang, Q; Christianson T A, Keeble W, Diaz J, Faulkner G R, Reifsteck C, Olson S, Bagby G C (Sep. 2001). "The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality". Blood (United States) 98 (5): 1392–401. doi:10.1182/blood.V98.5.1392. ISSN 0006-4971. PMID 11520787.
^ Zhang, J J; Vinkemeier U, Gu W, Chakravarti D, Horvath C M, Darnell J E (Dec. 1996). "Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15092–6. doi:10.1073/pnas.93.26.15092. ISSN 0027-8424. PMC 26361. PMID 8986769. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26361.
^ Takeda, Atsunobu; Hamano Shinjiro, Yamanaka Atsushi, Hanada Toshikatsu, Ishibashi Tatsuro, Mak Tak W, Yoshimura Akihiko, Yoshida Hiroki (May. 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. (United States) 170 (10): 4886–90. ISSN 0022-1767. PMID 12734330.
^ Liao, J; Fu Y, Shuai K (May. 2000). "Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (10): 5267–72. doi:10.1073/pnas.97.10.5267. ISSN 0027-8424. PMC 25817. PMID 10805787. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25817.
^ Ouchi, T; Lee S W, Ouchi M, Aaronson S A, Horvath C M (May. 2000). "Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (10): 5208–13. doi:10.1073/pnas.080469697. ISSN 0027-8424. PMC 25807. PMID 10792030. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25807.
^ Xie, B; Zhao J, Kitagawa M, Durbin J, Madri J A, Guan J L, Fu X Y (Jun. 2001). "Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion". J. Biol. Chem. (United States) 276 (22): 19512–23. doi:10.1074/jbc.M009063200. ISSN 0021-9258. PMID 11278462.
^ ^a ^b Kristof, Arnold S; Marks-Konczalik Joanna, Billings Eric, Moss Joel (Sep. 2003). "Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin". J. Biol. Chem. (United States) 278 (36): 33637–44. doi:10.1074/jbc.M301053200. ISSN 0021-9258. PMID 12807916.
^ Li, X; Leung S, Kerr I M, Stark G R (Apr. 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. (UNITED STATES) 17 (4): 2048–56. ISSN 0270-7306. PMC 232052. PMID 9121453. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232052.
^ ^a ^b Usacheva, A; Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (Jun. 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. (United States) 276 (25): 22948–53. doi:10.1074/jbc.M100087200. ISSN 0021-9258. PMID 11301323.
^ Wang, Y; Wu T R, Cai S, Welte T, Chin Y E (Jul. 2000). "Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4505–12. doi:10.1128/MCB.20.13.4505-4512.2000. ISSN 0270-7306. PMC 85828. PMID 10848577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85828.
^ Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E (Oct. 1999). "Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation". Mol. Cell. Biol. (UNITED STATES) 19 (10): 7138–46. ISSN 0270-7306. PMC 84707. PMID 10490649. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84707.
^ Vidal, Marcos; Ramana Chilakamarti V, Dusso Adriana S (Apr. 2002). "Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription". Mol. Cell. Biol. (United States) 22 (8): 2777–87. doi:10.1128/MCB.22.8.2777-2787.2002. ISSN 0270-7306. PMC 133712. PMID 11909970. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133712.
^ Horvath, C M; Stark G R, Kerr I M, Darnell J E (Dec. 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. (UNITED STATES) 16 (12): 6957–64. ISSN 0270-7306. PMC 231699. PMID 8943351. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231699.
^ Usacheva, Anna; Tian Xinyong, Sandoval Raudel, Salvi Debra, Levy David, Colamonici Oscar R (Sep. 2003). "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. Immunol. (United States) 171 (6): 2989–94. ISSN 0022-1767. PMID 12960323.

External links

FactorBook STAT1

PDB gallery

1bf5: TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX

1yvl: Structure of Unphosphorylated STAT1

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1

(1.3) bHLH-ZIP	AP-4 · MAX · MITF · MNT · MLX · MXI1 · Myc · SREBP (1, 2)

(1.4) NF-1	NFI (A, B, C, X) · SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)

(1.5) RF-X	RFX (1, 2, 3, 4, 5, ANK)

(1.6) Basic helix-span-helix (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Zinc finger DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1

(2.3) Cys₂His₂	General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B

(3) Helix-turn-helix domains

(3.1) Homeodomain	ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2) · DLX (3, 4, 5) · EMX2 · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B) · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · VAX1 · ZEB (1, 2)

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, I1, J1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2

(3.6) TEA domain	transcriptional enhancer factor (1, 2, 3, 4)

(4) β-Scaffold factors with minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53 · TBX (1, 2, 3, 5, 19, 21, 22, Brachyury, TBR1, TBR2) · TP63

(4.4) MADS box	Mef2 (A, B, C, D) · SRF

(4.6) TATA binding proteins	TBP · TBPL1

(4.7) High-mobility group	BBX · HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4) · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4)

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) · HBP1

(0.3) Pocket domain	Rb · RBL1 · RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 · EREBP · B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma

see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

JAK-STAT signaling pathway

Ligand

Cytokine

Cytokine receptor

Type I cytokine receptor · Type II cytokine receptor

Janus kinase

JAK1 · JAK2 · JAK3 · TYK2

Adaptor proteins

STAT	STAT1 · STAT2 · STAT3 · STAT4 · STAT5 · STAT6

PIAS	PIAS1 · PIAS2 · PIAS3 · PIAS4

SOCS	1, 2, 3, 4, 5, 6, 7

IRF	IRF1 · IRF2 · IRF3 · IRF4 · IRF5 · IRF6 · IRF7 · IRF8

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

STAT1

Contents

Interactions

References

Further reading

External links