Spondyloarthropathy is any joint disease of the vertebral column.[1] Spondyloarthropathy with inflammation is called spondylarthritis. In contrast, spondylopathy is a disease of the vertebra itself, but many conditions involve both spondylopathy and spondyloarthropathy. In the broadest sense, the term spondyloarthropathy includes joint involvement of vertebral column from any type of joint disease, including rheumatoid arthritis and osteoarthritis, but the term is often used for a specific group of disorders with certain common features, the group often being termed specifically seronegative spondylarthropathies:
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Seronegative spondyloarthropathy (or seronegative spondyloarthritis) is a group of diseases involving the axial skeleton[2] and having a negative serostatus.
"Seronegative" refers to the fact that these diseases are negative for rheumatoid factor,[3] indicating a different pathophysiological mechanism of disease than what is commonly seen in rheumatoid arthritis.
The following conditions in the table are typically included within the group of seronegative spondylarthropathies:
| Condition | Percent of people with the condition who are HLA-B27 positive |
|---|---|
| Ankylosing Spondylitis[4][5] |
|
| Reactive arthritis[4][5] (Reiter's syndrome) | 60-80% |
| enteropathic spondylitis or spondylitis associated with inflammatory bowel disease[4][5] (including Crohn's disease and ulcerative colitis) |
60% |
| Psoriatic arthritis[4][5] | 60% |
| Isolated acute anterior uveitis | 50% |
| Undifferentiated spondyloarthropathy[4][5] (USpA) | 20-25% |
Some sources also include Behcet's disease and Whipple's disease.[7]
These diseases have the following conditions in common:
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