Sorivudine
Sorivudine
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| Systematic (IUPAC) name |
| 1-β-D-arabinofuranosyl-5-[(E)-2-bromovinyl]pyrimidine-2,4(1H,3H)-dione |
| Clinical data |
| Pregnancy cat. |
? |
| Legal status |
? |
| Routes |
oral |
| Pharmacokinetic data |
| Metabolism |
Viral thymidine kinase |
| Excretion |
kidney |
| Identifiers |
| CAS number |
77181-69-2 Y |
| ATC code |
J05AB15 |
| PubChem |
CID 5282192 |
| UNII |
C7VOZ162LV N |
| KEGG |
D01734 Y |
| ChEMBL |
CHEMBL375035 N |
| Synonyms |
BV-araU, Bromovinyl araU, 5-Bromovinyl-araU, 5-[(E)-2-bromoethenyl]-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| Chemical data |
| Formula |
C11H13BrN2O6 |
| Mol. mass |
349.14 g/mol |
N(what is this?) (verify)
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Sorivudine (INN) chemical name (E)-5-(2-Bromovinyl)- 1β-D-arabinofuranosyluracil, is a thymine analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS).
Pharmacology
Feature
- First-line treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
- Superior gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted as urine.
Mechanism of action
- Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA, to inhibit viral DNA replication of DNA polymerase to make it fail to inhibit viral growth.
Microbiology
Sorivudine is active against most species in the herpesvirus family.
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| Baltimore I |
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DNA-synthesis
inhibitor
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Other
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| Hepatitis B (VII) |
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| Multiple/general |
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Nucleic acid inhibitors
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Multiple/unknown
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ErbB2/PI3K Pathway
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NOV-205§ • NOV-002†
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cutn/syst (hppv/hiva, infl/zost/zoon)/epon
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drugJ(dnaa, rnaa, rtva, vacc)
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