Sorbinil

Sorbinil

IUPAC name (4S)-6-Fluoro-2,3-dihydro-2’H,5’H-spiro[chromene-4,4’-imidazolidine]-2’,5’-dione
Other names (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione; CP 45634
Identifiers
CAS number	68367-52-2
PubChem	337359
ChemSpider	298991
ChEMBL	CHEMBL7681
Jmol-3D images	Image 1
SMILES Fc3ccc2OCC[C@@]1(C(=O)NC(=O)N1)c2c3
InChI InChI=InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
Properties^[1]
Molecular formula	C₁₁H₉FN₂O₃
Molar mass	236.2 g mol⁻¹
Appearance	White to off-white powder
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Sorbinil is an aldose reductase inhibitor being investigated for treatment of diabetic complications including neuropathy and retinopathy.^[2]

References

^ Sorbinil at Sigma-Aldrich
^ MacCari, R; Del Corso, A; Giglio, M; Moschini, R; Mura, U; Ottanà, R (2011). "In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors". Bioorganic & medicinal chemistry letters 21 (1): 200–3. doi:10.1016/j.bmcl.2010.11.041. PMID 21129963.