| Somatostatinoma | |
|---|---|
| Classification and external resources | |
| ICD-O: | M8156/1 |
| DiseasesDB | 12277 |
| eMedicine | med/2145 |
| MeSH | D013005 |
Somatostatinoma is a tumor of the delta cells of the endocrine pancreas that produces somatostatin.
It is associated with diabetes mellitus and abnormal glucose tolerance.
Triad of : Mild Diabetes mellitus, Steatorrhoea, Gall stones. also associated with hypochlorhydria.
Commonly found in head of pancreas, and are malignant.
Elevated plasma levels of Somatostatin.
in a normal subject actions of Somatostatin include:
This explaining how abnormally elevatedSomatostatin can cause Diabetes mellitus, by inhibiting insulin secretion, Steatorrhoea by inhibiting Cholecystokinin and Secretin, Gall stones by inhibiting Cholecystokinin which normally induce gallbladder myocytes contraction, and hypochlorhydria caused by inhibiting Gastrin, which normally stimulate acid secretion.
Treatment is by chemotherapy with streptozocin, dacarbazine, doxorubicin.
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