Solvophobic theory/ solvophobicity attempts to explain interactions between polar solvents and non-polar solutes. The molecular structure of the solvent molecule is driven by hydrogen bonding between similarly structured solvent molecules but is perturbed by non-polar solute molecules.[1] When applied to liquid chromatography (LC), solvophobic theory attributes the retention of solutes on the stationary phase to the active rejection of solute molecules by the solvent. However, in practice attractive forces between the solvent and the stationary phase play a role in driving the retention of solvents in LC systems.[2]