Dirlotapide

Dirlotapide
Systematic (IUPAC) name
1-Methyl-N-[(1S)-2-(methyl-(phenylmethyl)amino)-2-oxo-1-phenylethyl]-5-[ [oxo-[2-[4-(trifluoromethyl)phenyl]phenyl]methyl]amino]-2-indolecarboxamide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 481658-94-0
ATCvet code QA08AB91
PubChem CID 9917862
ChemSpider 8093509 Y
UNII 578H0RMP25 Y
KEGG D03867 Y
ChEMBL CHEMBL410414 Y
Chemical data
Formula C40H33F3N4O3 
Mol. mass 674.71 g/mol
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

Dirlotapide is a drug used to treat obesity in dogs. It is manufactured by Pfizer and marketed as Slentrol.

It works as a selective microsomal triglyceride transfer protein inhibitor. This blocks the assembly and release of lipoproteins into the bloodstream, thereby reducing fat absorption. It also elicits a satiety signal from lipid-filled cells lining the intestine.

It is supplied as an oral solution. It is not intended for use in humans, cats, or parrots.

On January 5 2007, the U.S. Food and Drug Administration (FDA) approved Slentrol, the first time the FDA has approved a drug for obese dogs.[1]

References

  1. ^ "FDA approves 1st drug for obese dogs". Yahoo. Archived from the original on January 8, 2007. http://web.archive.org/web/20070108052816/http://news.yahoo.com/s/ap/20070106/ap_on_he_me/doggie_diet_drug. Retrieved 2007-01-06. 

External links