SIRT7

Sirtuin 7
Identifiers
Symbols SIRT7; MGC126840; MGC126842; SIR2L7
External IDs OMIM606212 MGI2385849 HomoloGene56152 GeneCards: SIRT7 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 51547 209011
Ensembl ENSG00000187531 ENSMUSG00000025138
UniProt Q9NRC8 Q8BKJ9
RefSeq (mRNA) NM_016538 NM_153056.2
RefSeq (protein) NP_057622 NP_694696.2
Location (UCSC) Chr 17:
79.87 – 79.88 Mb
Chr 11:
120.48 – 120.49 Mb
PubMed search [1] [2]

NAD-dependent deacetylase sirtuin-7 is an enzyme that in humans is encoded by the SIRT7 gene.[1][2][3]

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.[3]

References

Further reading