SIRT7
NAD-dependent deacetylase sirtuin-7 is an enzyme that in humans is encoded by the SIRT7 gene.[1][2][3]
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.[3]
References
Further reading
- de Nigris F, Cerutti J, Morelli C, et al. (2002). "Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.". Br. J. Cancer 86 (6): 917–23. doi:10.1038/sj.bjc.6600156. PMC 2364158. PMID 11953824. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2364158.
- De Nigris F, Cerutti J, Morelli C, et al. (2003). "Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.". Br. J. Cancer 87 (12): 1479. doi:10.1038/sj.bjc.6600636. PMC 2376288. PMID 12454780. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2376288.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Voelter-Mahlknecht S, Letzel S, Mahlknecht U (2006). "Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene.". Int. J. Oncol. 28 (4): 899–908. PMID 16525639.
- Ashraf N, Zino S, Macintyre A, et al. (2006). "Altered sirtuin expression is associated with node-positive breast cancer.". Br. J. Cancer 95 (8): 1056–61. doi:10.1038/sj.bjc.6603384. PMC 2360714. PMID 17003781. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2360714.