Sgs1

Sgs1, also known as small growth suppressor 1,[1] is a DNA helicase protein found in Saccharomyces cerevisiae. It is a homolog of the bacterial RecQ helicase. Like the other members of the RecQ helicase family, Sgs1 is important for DNA repair. In particular, Sgs1 collaborates with other proteins to repair double-strand breaks during homologous recombination in eukaryotes.[2]

References

  1. ^ Gangloff, S et al (December 1994). "The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase". Molecular and Cellular Biology 14 (12): 8391–8398. PMC 359378. PMID 7969174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359378. 
  2. ^ Mimitou, EP; Symington, LS (9 October 2008). Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. 455. pp. 770–774. doi:10.1038/nature07312. PMID 18806779.