SYNE2

Spectrin repeat containing, nuclear envelope 2

Identifiers

SYNE2; DKFZp434H2235; DKFZp686E01115; DKFZp686H1931; EDMD5; FLJ11014; FLJ43727; FLJ45710; FLJ46790; KIAA1011; NUA; NUANCE; Nesprin-2; SYNE-2; TROPH

External IDs

OMIM: 608442 MGI: 2449316 HomoloGene: 56700 GeneCards: SYNE2 Gene

Gene Ontology
Molecular function	• actin binding • protein binding
Cellular component	• nucleus • nuclear envelope • nuclear outer membrane • nucleoplasm • cytoplasm • cytoskeleton • plasma membrane • focal adhesion • integral to membrane • sarcoplasmic reticulum • Z disc • lamellipodium membrane • filopodium membrane • nuclear membrane • nuclear lumen • sarcoplasmic reticulum membrane • SUN-KASH complex • mitochondrial part
Biological process	• nuclear migration • positive regulation of cell migration • nuclear migration along microfilament • centrosome localization • cytoskeletal anchoring at nuclear membrane
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
64.32 – 64.69 Mb

Chr 12:
76.92 – 77.21 Mb

PubMed search

[1]

[2]

Nesprin-2 is a protein that in humans is encoded by the SYNE2 gene.^[1]^[2]^[3]

References

^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
^ Apel ED, Lewis RM, Grady RM, Sanes JR (Nov 2000). "Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction". J Biol Chem 275 (41): 31986–95. doi:10.1074/jbc.M004775200. PMID 10878022.
^ "Entrez Gene: SYNE2 spectrin repeat containing, nuclear envelope 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23224.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Zhang Q, Skepper JN, Yang F, et al. (2002). "Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.". J. Cell. Sci. 114 (Pt 24): 4485–98. PMID 11792814.
Zhen YY, Libotte T, Munck M, et al. (2003). "NUANCE, a giant protein connecting the nucleus and actin cytoskeleton.". J. Cell. Sci. 115 (Pt 15): 3207–22. PMID 12118075.
Zhang Q, Ragnauth C, Greener MJ, et al. (2003). "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.". Genomics 80 (5): 473–81. doi:10.1016/S0888-7543(02)96859-X. PMID 12408964.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Schirmer EC, Florens L, Guan T, et al. (2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics.". Science 301 (5638): 1380–2. doi:10.1126/science.1088176. PMID 12958361.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Zhang Q, Ragnauth CD, Skepper JN, et al. (2005). "Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle.". J. Cell. Sci. 118 (Pt 4): 673–87. doi:10.1242/jcs.01642. PMID 15671068.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
Libotte T, Zaim H, Abraham S, et al. (2005). "Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope.". Mol. Biol. Cell 16 (7): 3411–24. doi:10.1091/mbc.E04-11-1009. PMC 1165422. PMID 15843432. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1165422.
Padmakumar VC, Libotte T, Lu W, et al. (2005). "The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.". J. Cell. Sci. 118 (Pt 15): 3419–30. doi:10.1242/jcs.02471. PMID 16079285.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wheeler MA, Davies JD, Zhang Q, et al. (2007). "Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.". Exp. Cell Res. 313 (13): 2845–57. doi:10.1016/j.yexcr.2007.03.025. PMID 17462627.

SYNE2

References

Further reading