SWAP70

SWAP switching B-cell complex 70kDa subunit

PDB rendering based on 2dn6.

Available structures
PDB	2dn6

Identifiers

Symbols

SWAP70; FLJ39540; KIAA0640; SWAP-70

External IDs

OMIM: 604762 MGI: 1298390 HomoloGene: 7557 GeneCards: SWAP70 Gene

Gene Ontology
Molecular function	• DNA binding • calcium ion binding • ATP binding
Cellular component	• nucleus • cytoplasm • plasma membrane • lamellipodium
Biological process	• somatic cell DNA recombination • isotype switching
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
9.69 – 9.77 Mb

Chr 7:
117.37 – 117.43 Mb

PubMed search

[1]

[2]

Switch-associated protein 70 is a protein that in humans and other mammals is encoded by the SWAP70 gene.^[1]^[2]^[3]^[4]

References

^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Masat L, Caldwell J, Armstrong R, Khoshnevisan H, Jessberger R, Herndier B, Wabl M, Ferrick D (Apr 2000). "Association of SWAP-70 with the B cell antigen receptor complex". Proc Natl Acad Sci U S A 97 (5): 2180–4. doi:10.1073/pnas.040374497. PMC 15774. PMID 10681448. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15774.
^ "Entrez Gene: SWAP70 SWAP-70 protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23075.
^ Pearce G, Angeli V, Randolph GJ, Junt T, von Andrian U, Schnittler HJ, Jessberger R (August 2006). "Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs". Nat. Immunol. 7 (8): 827–34. doi:10.1038/ni1365. PMID 16845395.

Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex.". J. Biol. Chem. 273 (27): 17025–35. doi:10.1074/jbc.273.27.17025. PMID 9642267.
Rapalus L, Minegishi Y, Lavoie A, et al. (2002). "Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency.". Clin. Immunol. 101 (3): 270–5. doi:10.1006/clim.2001.5116. PMID 11726218.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hilpelä P, Oberbanscheidt P, Hahne P, et al. (2004). "SWAP-70 identifies a transitional subset of actin filaments in motile cells.". Mol. Biol. Cell 14 (8): 3242–53. doi:10.1091/mbc.E03-01-0043. PMC 181564. PMID 12925760. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=181564.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Ihara S, Oka T, Fukui Y (2006). "Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling.". J. Cell. Sci. 119 (Pt 3): 500–7. doi:10.1242/jcs.02767. PMID 16418221.
Kimbara N, Dohi N, Miyamoto M, et al. (2006). "Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells.". Microbiol. Immunol. 50 (3): 235–42. PMID 16547421.
Liu J, Li D, Cao B, et al. (2007). "Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation.". J. Histochem. Cytochem. 55 (7): 701–8. doi:10.1369/jhc.6A7151.2007. PMID 17371938.

PDB gallery

2dn6: Solution structure of the PH domain of KIAA0640 protein from human

SWAP70

References

Further reading