SUMO4

SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
Identifiers
Symbols SUMO4; IDDM5; SMT3H4; SUMO-4; dJ281H8.4
External IDs OMIM: 608829 HomoloGene: 88399 GeneCards: SUMO4 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 387082 n/a
Ensembl ENSG00000177688 n/a
UniProt Q6EEV6 n/a
RefSeq (mRNA) NM_001002255 n/a
RefSeq (protein) NP_001002255 n/a
Location (UCSC) Chr 6:
149.72 – 149.72 Mb		 n/a
PubMed search [1] n/a

Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene.[1][2]

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.[2]

Interactions

SUMO4 has been shown to interact with IκBα.[3]

References

  1. ^ Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D (Jun 2004). "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus". J Biol Chem 279 (26): 27233–8. doi:10.1074/jbc.M402273200. PMID 15123604. 
  2. ^ a b "Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387082. 
  3. ^ Guo, Dehuang; Li Manyu, Zhang Yan, Yang Ping, Eckenrode Sarah, Hopkins Diane, Zheng Weipeng, Purohit Sharad, Podolsky Robert H, Muir Andrew, Wang Jinzhao, Dong Zheng, Brusko Todd, Atkinson Mark, Pozzilli Paolo, Zeidler Adina, Raffel Leslie J, Jacob Chaim O, Park Yongsoo, Serrano-Rios Manuel, Larrad Maria T Martinez, Zhang Zixin, Garchon Henri-Jean, Bach Jean-Francois, Rotter Jerome I, She Jin-Xiong, Wang Cong-Yi (Aug. 2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes". Nat. Genet. (United States) 36 (8): 837–41. doi:10.1038/ng1391. ISSN 1061-4036. PMID 15247916. 

Further reading

  • Wang CY, Podolsky R, She JX (2007). "Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene.". Ann. N. Y. Acad. Sci. 1079 (1): 257–67. Bibcode 2006NYASA1079..257W. doi:10.1196/annals.1375.039. PMID 17130563. 
  • Davies JL, Kawaguchi Y, Bennett ST, et al. (1994). "A genome-wide search for human type 1 diabetes susceptibility genes.". Nature 371 (6493): 130–6. doi:10.1038/371130a0. PMID 8072542. 
  • Luo DF, Buzzetti R, Rotter JI, et al. (1997). "Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8.". Hum. Mol. Genet. 5 (5): 693–8. doi:10.1093/hmg/5.5.693. PMID 8733139. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Guo D, Li M, Zhang Y, et al. (2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.". Nat. Genet. 36 (8): 837–41. doi:10.1038/ng1391. PMID 15247916. 
  • Smyth DJ, Howson JM, Lowe CE, et al. (2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.". Nat. Genet. 37 (2): 110–1; author reply 112–3. doi:10.1038/ng0205-110. PMID 15678134. 
  • Qu H, Bharaj B, Liu XQ, et al. (2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.". Nat. Genet. 37 (2): 111–2; author reply 112–3. doi:10.1038/ng0205-111. PMID 15678135. 
  • Park Y, Park S, Kang J, et al. (2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.". Nat. Genet. 37 (2): 112; author reply 112–3. doi:10.1038/ng0205-112a. PMID 15678137. 
  • Owerbach D, McKay EM, Yeh ET, et al. (2005). "A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation.". Biochem. Biophys. Res. Commun. 337 (2): 517–20. doi:10.1016/j.bbrc.2005.09.090. PMID 16198310. 
  • Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267. 
  • Noso S, Ikegami H, Fujisawa T, et al. (2006). "Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.". Diabetes 54 (12): 3582–6. doi:10.2337/diabetes.54.12.3582. PMID 16306380. 
  • Tsurumaru M, Kawasaki E, Ida H, et al. (2006). "Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.". J. Clin. Endocrinol. Metab. 91 (8): 3138–43. doi:10.1210/jc.2006-0206. PMID 16735488. 
  • Costas J, Perez-Pampin E, Ferreiros-Vidal I, et al. (2006). "SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis.". J. Rheumatol. 33 (6): 1048–51. PMID 16755651. 
  • Sedimbi SK, Shastry A, Park Y, et al. (2007). "Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients.". Ann. N. Y. Acad. Sci. 1079 (1): 273–7. doi:10.1196/annals.1375.041. PMID 17130565. 
  • Lin HY, Wang CL, Hsiao PJ, et al. (2007). "SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes.". Diabetes 56 (4): 1177–80. doi:10.2337/db06-1283. PMID 17229939. 
  • Sedimbi SK, Kanungo A, Shastry A, et al. (2007). "No association of SUMO4 M55V with autoimmune diabetes in Asian-Indian patients.". Int. J. Immunogenet. 34 (2): 137–42. doi:10.1111/j.1744-313X.2007.00668.x. PMID 17373940. 
  • Noso S, Fujisawa T, Kawabata Y, et al. (2007). "Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.". J. Clin. Endocrinol. Metab. 92 (6): 2358–62. doi:10.1210/jc.2007-0031. PMID 17374705. 
  • Bohren KM, Gabbay KH, Owerbach D (2007). "Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin.". Protein Expr. Purif. 54 (2): 289–94. doi:10.1016/j.pep.2007.03.013. PMID 17459725.