SUB1

SUB1 homolog (S. cerevisiae)

PDB rendering based on 1pcf.

Available structures
PDB	1PCF, 2C62, 2PHE

Identifiers

Symbols

SUB1; MGC102747; P15; PC4; p14

External IDs

OMIM: 600503 MGI: 104811 HomoloGene: 38218 GeneCards: SUB1 Gene

Gene Ontology
Molecular function	• DNA binding • single-stranded DNA binding • transcription coactivator activity • protein binding
Cellular component	• nucleus • transcription factor complex • nucleolus
Biological process	• regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
32.53 – 32.6 Mb

Chr 15:
11.91 – 11.93 Mb

PubMed search

[1]

[2]

Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene.^[1]^[2]^[3] The human SUB1 gene^[3] is named after an orthologous gene in yeast.^[4]

Interactions

SUB1 has been shown to interact with CSTF2.^[5]

References

^ Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M (Sep 1994). "A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators". Cell 78 (3): 525–34. doi:10.1016/0092-8674(94)90429-4. PMID 8062392.
^ Ge H, Roeder RG (Sep 1994). "Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes". Cell 78 (3): 513–23. doi:10.1016/0092-8674(94)90428-6. PMID 8062391.
^ ^a ^b "Entrez Gene SUB1: SUB1 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10923.
^ Knaus R, Pollock R, Guarente L (April 1996). "Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4". EMBO J. 15 (8): 1933–40. PMC 450112. PMID 8617240. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=450112.
^ Calvo, O; Manley J L (May. 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell (United States) 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. ISSN 1097-2765. PMID 11389848.

Kaiser K, Stelzer G, Meisterernst M (1995). "The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation.". EMBO J. 14 (14): 3520–7. PMC 394420. PMID 7628453. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=394420.
Ge H, Zhao Y, Chait BT, Roeder RG (1995). "Phosphorylation negatively regulates the function of coactivator PC4.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12691–5. doi:10.1073/pnas.91.26.12691. PMC 45505. PMID 7809103. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=45505.
Brandsen J, Werten S, van der Vliet PC, et al. (1997). "C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.". Nat. Struct. Biol. 4 (11): 900–3. doi:10.1038/nsb1197-900. PMID 9360603.
Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. doi:10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19292.
Luo Y, Ge H, Stevens S, et al. (1998). "Coactivation by OCA-B: definition of critical regions and synergism with general cofactors.". Mol. Cell. Biol. 18 (7): 3803–10. PMC 108964. PMID 9632764. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108964.
Currie RA (1998). "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development.". J. Biol. Chem. 273 (29): 18220–9. doi:10.1074/jbc.273.29.18220. PMID 9660784.
Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III.". Mol. Cell 1 (5): 749–57. doi:10.1016/S1097-2765(00)80074-X. PMID 9660958.
Holloway AF, Occhiodoro F, Mittler G, et al. (2000). "Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells.". J. Biol. Chem. 275 (28): 21668–77. doi:10.1074/jbc.M909058199. PMID 10887206.
Yuan CX, Gurley WB (2001). "Potential targets for HSF1 within the preinitiation complex.". Cell Stress Chaperones 5 (3): 229–42. doi:10.1379/1466-1268(2000)005<0229:PTFHWT>2.0.CO;2. ISSN 1466-1268. PMC 312889. PMID 11005381. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312889.
Kumar BR, Swaminathan V, Banerjee S, Kundu TK (2001). "p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation". J. Biol. Chem. 276 (20): 16804–9. doi:10.1074/jbc.M100934200. PMID 11279157.
Yu P, Huang B, Shen M, et al. (2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene 20 (4): 484–9. doi:10.1038/sj.onc.1204113. PMID 11313979.
Calvo O, Manley JL (2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. PMID 11389848.
Guo H, Cai CQ, Kuo PC (2002). "Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription". J. Biol. Chem. 277 (7): 5054–60. doi:10.1074/jbc.M109017200. PMID 11741883.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Dubois T, Zemlickova E, Howell S, Aitken A (2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochem. Biophys. Res. Commun. 301 (2): 502–8. doi:10.1016/S0006-291X(02)03010-3. PMID 12565890.
Fukuda A, Tokonabe S, Hamada M, et al. (2003). "Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH". J. Biol. Chem. 278 (17): 14827–31. doi:10.1074/jbc.M213172200. PMID 12590132.
Swietlicki E, Iordanov H, Fritsch C, et al. (2003). "Growth factor regulation of PC4/TIS7, an immediate early gene expressed during gut adaptation after resection". JPEN. Journal of parenteral and enteral nutrition 27 (2): 123–31. doi:10.1177/0148607103027002123. PMID 12665168.
Banerjee S, Kumar BR, Kundu TK (2004). "General transcriptional coactivator PC4 activates p53 function". Mol. Cell. Biol. 24 (5): 2052–62. doi:10.1128/MCB.24.5.2052-2062.2004. PMC 350566. PMID 14966284. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=350566.

PDB gallery

1pcf: HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN

2c62: CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA

2phe: Model for VP16 binding to PC4

SUB1

Interactions

References

Further reading