STX4
Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.[1][2][3]
Interactions
STX4 has been shown to interact with SNAP-25,[4][5][6][7] NAPA,[8] STXBP5,[9] SNAP23,[5][7][10][11][12][13][14][15] Vesicle-associated membrane protein 8,[13][16] RAB4A,[17] TXLNB,[18] VAMP2,[6][13][19][20] VAMP3,[8][10][13][16] STXBP1[4][21] and Syntaxin binding protein 3.[9][21]
References
- ^ Li H, Hodge DR, Pei GK, Seth A (Jul 1994). "Isolation and sequence analysis of the human syntaxin-encoding gene". Gene 143 (2): 303–4. doi:10.1016/0378-1119(94)90117-1. PMID 8206394.
- ^ Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T (Jan 2006). "Syntaxins 3 and 4 Are Concentrated in Separate Clusters on the Plasma Membrane before the Establishment of Cell Polarity". Mol Biol Cell 17 (2): 977–89. doi:10.1091/mbc.E05-05-0462. PMC 1356605. PMID 16339081. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356605.
- ^ "Entrez Gene: STX4 Syntaxin 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6810.
- ^ a b Hata, Y; Südhof T C (Jun. 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. (UNITED STATES) 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. ISSN 0021-9258. PMID 7768895.
- ^ a b Ravichandran, V; Chawla A, Roche P A (Jun. 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. (UNITED STATES) 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. ISSN 0021-9258. PMID 8663154.
- ^ a b Reed, G L; Houng A K, Fitzgerald M L (Apr. 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood (UNITED STATES) 93 (8): 2617–26. ISSN 0006-4971. PMID 10194441.
- ^ a b Steegmaier, M; Yang B, Yoo J S, Huang B, Shen M, Yu S, Luo Y, Scheller R H (Dec. 1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. (UNITED STATES) 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. ISSN 0021-9258. PMID 9852078.
- ^ a b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ^ a b Widberg, Charlotte H; Bryant Nia J, Girotti Milena, Rea Shane, James David E (Sep. 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. (United States) 278 (37): 35093–101. doi:10.1074/jbc.M304261200. ISSN 0021-9258. PMID 12832401.
- ^ a b Imai, Akane; Nashida Tomoko, Yoshie Sumio, Shimomura Hiromi (Aug. 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. (England) 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. ISSN 0003-9969. PMID 12828989.
- ^ Li, Guangmu; Alexander Edward A, Schwartz John H (May. 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". J. Biol. Chem. (United States) 278 (22): 19791–7. doi:10.1074/jbc.M212250200. ISSN 0021-9258. PMID 12651853.
- ^ Araki, S; Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May. 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. (UNITED STATES) 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. ISSN 0006-291X. PMID 9168999.
- ^ a b c d Paumet, F; Le Mao J, Martin S, Galli T, David B, Blank U, Roa M (Jun. 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". J. Immunol. (UNITED STATES) 164 (11): 5850–7. ISSN 0022-1767. PMID 10820264.
- ^ Kawanishi, M; Tamori Y, Okazawa H, Araki S, Shinoda H, Kasuga M (Mar. 2000). "Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2". J. Biol. Chem. (UNITED STATES) 275 (11): 8240–7. doi:10.1074/jbc.275.11.8240. ISSN 0021-9258. PMID 10713150.
- ^ Freedman, Steven J; Song Hyun Kyu, Xu Yingwu, Sun Zhen-Yu J, Eck Michael J (Apr. 2003). "Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain". J. Biol. Chem. (United States) 278 (15): 13462–7. doi:10.1074/jbc.M210483200. ISSN 0021-9258. PMID 12556468.
- ^ a b Polgár, János; Chung Sul-Hee, Reed Guy L (Aug. 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood (United States) 100 (3): 1081–3. doi:10.1182/blood.V100.3.1081. ISSN 0006-4971. PMID 12130530.
- ^ Li, L; Omata W, Kojima I, Shibata H (Feb. 2001). "Direct interaction of Rab4 with syntaxin 4". J. Biol. Chem. (United States) 276 (7): 5265–73. doi:10.1074/jbc.M003883200. ISSN 0021-9258. PMID 11063739.
- ^ Nogami, Satoru; Satoh Sachie, Tanaka-Nakadate Sawako, Yoshida Kenji, Nakano Michiko, Terano Akira, Shirataki Hiromichi (Jul. 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. (United States) 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. ISSN 0006-291X. PMID 15184072.
- ^ Mollinedo, Faustino; Martín-Martín Belén, Calafat Jero, Nabokina Svetlana M, Lazo Pedro A (Jan. 2003). "Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary granules of human neutrophils". J. Immunol. (United States) 170 (2): 1034–42. ISSN 0022-1767. PMID 12517971.
- ^ Jagadish, M N; Fernandez C S, Hewish D R, Macaulay S L, Gough K H, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel M J, Ward C W (Aug. 1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". Biochem. J. (ENGLAND) 317 ( Pt 3) (Pt 3): 945–54. ISSN 0264-6021. PMC 1217577. PMID 8760387. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1217577.
- ^ a b Schraw, Todd D; Lemons Paula P, Dean William L, Whiteheart Sidney W (Aug. 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. (England) 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. ISSN 0264-6021. PMC 1223584. PMID 12773094. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223584.
Further reading
- Bennett MK, García-Arrarás JE, Elferink LA, et al. (1993). "The syntaxin family of vesicular transport receptors". Cell 74 (5): 863–73. doi:10.1016/0092-8674(93)90466-4. PMID 7690687.
- Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.
- Jagadish MN, Fernandez CS, Hewish DR, et al. (1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". Biochem. J. 317 ( Pt 3) (Pt 3): 945–54. PMC 1217577. PMID 8760387. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1217577.
- Mandon B, Chou CL, Nielsen S, Knepper MA (1996). "Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking". J. Clin. Invest. 98 (4): 906–13. doi:10.1172/JCI118873. PMC 507504. PMID 8770861. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=507504.
- Timmers KI, Clark AE, Omatsu-Kanbe M, et al. (1997). "Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein". Biochem. J. 320 ( Pt 2) (Pt 2): 429–36. PMC 1217948. PMID 8973549. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1217948.
- Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.
- Araki S, Tamori Y, Kawanishi M, et al. (1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.
- Inoue T, Nielsen S, Mandon B, et al. (1998). "SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles". Am. J. Physiol. 275 (5 Pt 2): F752–60. PMID 9815132.
- Reed GL, Houng AK, Fitzgerald ML (1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. PMID 10194441.
- Min J, Okada S, Kanzaki M, et al. (1999). "Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes". Mol. Cell 3 (6): 751–60. doi:10.1016/S1097-2765(01)80007-1. PMID 10394363.
- Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and Biochemical Analysis of the C2 Domains of Synaptotagmin IV". Mol. Biol. Cell 10 (7): 2285–95. PMC 25443. PMID 10397765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25443.
- Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Paumet F, Le Mao J, Martin S, et al. (2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". J. Immunol. 164 (11): 5850–7. PMID 10820264.
- Li L, Omata W, Kojima I, Shibata H (2001). "Direct interaction of Rab4 with syntaxin 4". J. Biol. Chem. 276 (7): 5265–73. doi:10.1074/jbc.M003883200. PMID 11063739.
- Logan MR, Lacy P, Bablitz B, Moqbel R (2002). "Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis". J. Allergy Clin. Immunol. 109 (2): 299–306. doi:10.1067/mai.2002.121453. PMID 11842301.
- Dent J, Kato K, Peng XR, et al. (2002). "A prototypic platelet septin and its participation in secretion". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 3064–9. doi:10.1073/pnas.052715199. PMC 122473. PMID 11880646. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122473.
- Perskvist N, Roberg K, Kulyté A, Stendahl O (2002). "Rab5a GTPase regulates fusion between pathogen-containing phagosomes and cytoplasmic organelles in human neutrophils". J. Cell. Sci. 115 (Pt 6): 1321–30. PMID 11884531.
- Polgár J, Chung SH, Reed GL (2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood 100 (3): 1081–3. doi:10.1182/blood.V100.3.1081. PMID 12130530.
- Scales SJ, Hesser BA, Masuda ES, Scheller RH (2002). "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly". J. Biol. Chem. 277 (31): 28271–9. doi:10.1074/jbc.M204929200. PMID 12145319.
|
|
|
| Synaptic vesicle |
|
|
|
|
SNAP25 · SNAP29
Syntaxin (STX1A, STX1B, STX2, STX3, STX4, STX5, STX6, STX7, STX8, STX10, STX11, STX12, STX16, STX17, STX18, STX19)
Munc-18: STXBP1 · STXBP2 · STXBP3 · STXBP4 · STXBP5 · STXBP6
|
|
|
|
|
|
|
|
|
|
|
|
Other
|
|
|
|
| COPI |
|
|
| COPII |
|
|
| RME/Clathrin |
|
|
| Caveolae |
|
|
| Other/ungrouped |
|
|
|
see also vesicular transport protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr
|
|