STRAP

Serine/threonine kinase receptor associated protein

Identifiers

STRAP; MAWD; PT-WD; UNRIP

External IDs

OMIM: 605986 MGI: 1329037 HomoloGene: 43881 GeneCards: STRAP Gene

Gene Ontology
Molecular function	• receptor binding • protein binding • identical protein binding
Cellular component	• nucleus • spliceosomal complex • cytoplasm • mitochondrion • plasma membrane • cell junction
Biological process	• negative regulation of transcription from RNA polymerase II promoter • mRNA processing • RNA splicing • negative regulation of transforming growth factor beta receptor signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000023734

ENSMUSG00000030224

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
16.04 – 16.06 Mb

Chr 6:
137.68 – 137.7 Mb

PubMed search

Serine-threonine kinase receptor-associated protein is an enzyme that in humans is encoded by the STRAP gene.^[1]

Interactions

STRAP has been shown to interact with Mothers against decapentaplegic homolog 6,^[2] TGF beta receptor 2,^[3]^[2] Mothers against decapentaplegic homolog 7,^[2] TGF beta receptor 1,^[3]^[2] Mothers against decapentaplegic homolog 3^[2] and Mothers against decapentaplegic homolog 2.^[2]

References

^ "Entrez Gene: STRAP serine/threonine kinase receptor associated protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11171.
^ ^a ^b ^c ^d ^e ^f Datta, P K; Moses H L (May. 2000). "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling". Mol. Cell. Biol. (UNITED STATES) 20 (9): 3157–67. doi:10.1128/MCB.20.9.3157-3167.2000. ISSN 0270-7306. PMC 85610. PMID 10757800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85610.
^ ^a ^b Datta, P K; Chytil A, Gorska A E, Moses H L (Dec. 1998). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling". J. Biol. Chem. (UNITED STATES) 273 (52): 34671–4. doi:10.1074/jbc.273.52.34671. ISSN 0021-9258. PMID 9856985.

Further reading

Datta PK, Chytil A, Gorska AE, Moses HL (1999). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling.". J. Biol. Chem. 273 (52): 34671–4. doi:10.1074/jbc.273.52.34671. PMID 9856985.
Hunt SL, Hsuan JJ, Totty N, Jackson RJ (1999). "unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA.". Genes Dev. 13 (4): 437–48. doi:10.1101/gad.13.4.437. PMC 316477. PMID 10049359. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316477.
Matsuda S, Katsumata R, Okuda T, et al. (2000). "Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer.". Cancer Res. 60 (1): 13–7. PMID 10646843.
Datta PK, Moses HL (2000). "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.". Mol. Cell. Biol. 20 (9): 3157–67. doi:10.1128/MCB.20.9.3157-3167.2000. PMC 85610. PMID 10757800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85610.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Iriyama C, Matsuda S, Katsumata R, Hamaguchi M (2001). "Cloning and sequencing of a novel human gene which encodes a putative hydroxylase.". J. Hum. Genet. 46 (5): 289–92. doi:10.1007/s100380170081. PMID 11355021.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Pillai RS, Grimmler M, Meister G, et al. (2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.". Genes Dev. 17 (18): 2321–33. doi:10.1101/gad.274403. PMC 196468. PMID 12975319. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=196468.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Ozdamar B, Bose R, Barrios-Rodiles M, et al. (2005). "Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.". Science 307 (5715): 1603–9. doi:10.1126/science.1105718. PMID 15761148.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Carissimi C, Baccon J, Straccia M, et al. (2005). "Unrip is a component of SMN complexes active in snRNP assembly.". FEBS Lett. 579 (11): 2348–54. doi:10.1016/j.febslet.2005.03.034. PMID 15848170.
Grimmler M, Otter S, Peter C, et al. (2006). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization.". Hum. Mol. Genet. 14 (20): 3099–111. doi:10.1093/hmg/ddi343. PMID 16159890.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
Seong HA, Jung H, Choi HS, et al. (2006). "Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.". J. Biol. Chem. 280 (52): 42897–908. doi:10.1074/jbc.M507539200. PMID 16251192.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Carissimi C, Saieva L, Gabanella F, Pellizzoni L (2007). "Gemin8 is required for the architecture and function of the survival motor neuron complex.". J. Biol. Chem. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.
Seong HA, Jung H, Ha H (2007). "NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.". J. Biol. Chem. 282 (16): 12075–96. doi:10.1074/jbc.M609832200. PMID 17314099.