STK39

Serine threonine kinase 39
Identifiers
Symbols STK39; DCHT; DKFZp686K05124; PASK; SPAK
External IDs OMIM607648 MGI1858416 HomoloGene22739 GeneCards: STK39 Gene
EC number 2.7.11.1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 27347 53416
Ensembl ENSG00000198648 ENSMUSG00000027030
UniProt Q9UEW8 Q3TR01
RefSeq (mRNA) NM_013233 NM_016866.2
RefSeq (protein) NP_037365 NP_058562.1
Location (UCSC) Chr 2:
168.81 – 169.1 Mb
Chr 2:
68.05 – 68.31 Mb
PubMed search [1] [2]

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.[1][2]

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.[2] Some studies suggest that this gene might be linked to high blood pressure.[3]

References

  1. ^ Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC, DeAizpurua HJ (Oct 2000). "SPAK, a STE20/SPS1-related kinase that activates the p38 pathway". Oncogene 19 (37): 4290–7. doi:10.1038/sj.onc.1203784. PMID 10980603. 
  2. ^ a b "Entrez Gene: STK39 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27347. 
  3. ^ "Reuters: Key gene linked to high blood pressure identified". 29 December 2008. http://www.reuters.com/article/healthNews/idUSTRE4BS55G20081229. 

Further reading