STK3

Serine/threonine kinase 3

Identifiers

STK3; FLJ90748; KRS1; MST2

External IDs

OMIM: 605030 MGI: 1928487 HomoloGene: 48420 GeneCards: STK3 Gene

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • magnesium ion binding • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • protein serine/threonine kinase activator activity • protein dimerization activity
Cellular component	• nucleus • cytoplasm
Biological process	• protein phosphorylation • protein phosphorylation • signal transduction • intracellular protein kinase cascade • hippo signaling cascade • positive regulation of apoptosis • positive regulation of protein serine/threonine kinase activity • negative regulation of canonical Wnt receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
99.41 – 99.96 Mb

Chr 15:
34.81 – 35.09 Mb

PubMed search

[1]

[2]

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.^[1]^[2]

Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996; Lee et al., 2001).[supplied by OMIM]^[2]

References

^ Taylor LK, Wang HC, Erikson RL (Nov 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc Natl Acad Sci U S A 93 (19): 10099–104. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38343.
^ ^a ^b "Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6788.

Creasy CL, Chernoff J (1995). "Cloning and characterization of a human protein kinase with homology to Ste20". J. Biol. Chem. 270 (37): 21695–700. doi:10.1074/jbc.270.37.21695. PMID 7665586.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
Creasy CL, Chernoff J (1996). "Cloning and characterization of a member of the MST subfamily of Ste20-like kinases". Gene 167 (1–2): 303–6. doi:10.1016/0378-1119(95)00653-2. PMID 8566796.
Bren A, Welch M, Blat Y, Eisenbach M (1996). "Signal termination in bacterial chemotaxis: CheZ mediates dephosphorylation of free rather than switch-bound CheY". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10090–3. doi:10.1073/pnas.93.19.10090. PMC 38341. PMID 8816756. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38341.
Wang HC, Fecteau KA (2000). "Detection of a novel quiescence-dependent protein kinase". J. Biol. Chem. 275 (33): 25850–7. doi:10.1074/jbc.M000818200. PMID 10840030.
Lee KK, Ohyama T, Yajima N, et al. (2001). "MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation". J. Biol. Chem. 276 (22): 19276–85. doi:10.1074/jbc.M005109200. PMID 11278283.
De Souza PM, Kankaanranta H, Michael A, et al. (2002). "Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis". Blood 99 (9): 3432–8. doi:10.1182/blood.V99.9.3432. PMID 11964314.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Deng Y, Pang A, Wang JH (2003). "Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis". J. Biol. Chem. 278 (14): 11760–7. doi:10.1074/jbc.M211085200. PMID 12554736.
Rabizadeh S, Xavier RJ, Ishiguro K, et al. (2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
O'Neill E, Rushworth L, Baccarini M, Kolch W (2005). "Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1". Science 306 (5705): 2267–70. doi:10.1126/science.1103233. PMID 15618521.
Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.
Oh HJ, Lee KK, Song SJ, et al. (2006). "Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis". Cancer Res. 66 (5): 2562–9. doi:10.1158/0008-5472.CAN-05-2951. PMID 16510573.
Callus BA, Verhagen AM, Vaux DL (2006). "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation". FEBS J. 273 (18): 4264–76. doi:10.1111/j.1742-4658.2006.05427.x. PMID 16930133.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Seidel C, Schagdarsurengin U, Blümke K, et al. (2007). "Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma". Mol. Carcinog. 46 (10): 865–71. doi:10.1002/mc.20317. PMID 17538946.
Matallanas D, Romano D, Yee K, et al. (2007). "RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein". Mol. Cell 27 (6): 962–75. doi:10.1016/j.molcel.2007.08.008. PMC 2821687. PMID 17889669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2821687.

Signaling pathway: Hippo signaling pathway

Receptor	FAT4

Adaptor protein	NF2 · FRMD6 · SAV1 · MOBKL1A, MOBKL1B

Kinase	MST1, MST2 · LATS1, LATS2

Transcription factor	YAP1, TAZ

Other/unknown	RASSF1

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

STK3

References

Further reading