STK16

Serine/threonine kinase 16

PDB rendering based on 2buj.

Available structures
PDB	2buj

Identifiers

Symbols

STK16; FLJ39635; KRCT; MGC16211; MPSK; PKL12; TSF1

External IDs

OMIM: 604719 MGI: 1313271 HomoloGene: 2739 GeneCards: STK16 Gene

EC number

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • DNA binding • protein serine/threonine kinase activity • protein binding • ATP binding
Cellular component	• membrane
Biological process	• protein complex assembly • protein phosphorylation • positive regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
220.11 – 220.12 Mb

Chr 1:
75.21 – 75.21 Mb

PubMed search

[1]

[2]

Serine/threonine-protein kinase 16 is an enzyme that in humans is encoded by the STK16 gene.^[1]^[2]

Interactions

STK16 has been shown to interact with NAGK.^[3]

References

^ Ligos JM, Gerwin N, Fernandez P, Gutierrez-Ramos JC, Bernad A (Sep 1998). "Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases". Biochem Biophys Res Commun 249 (2): 380–384. doi:10.1006/bbrc.1998.9163. PMID 9712705.
^ "Entrez Gene: STK16 serine/threonine kinase 16". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8576.
^ Ligos, Jose Manuel; de Lera Teresa Laín, Hinderlich Stephan, Guinea Bárbara, Sánchez Luis, Roca Ramón, Valencia Alfonso, Bernad Antonio (Feb. 2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". J. Biol. Chem. (United States) 277 (8): 6333–6343. doi:10.1074/jbc.M105766200. ISSN 0021-9258. PMID 11741987.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Berson AE, Young C, Morrison SL et al. (1999). "Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase". Biochem. Biophys. Res. Commun. 259 (3): 533–538. doi:10.1006/bbrc.1999.0811. PMID 10364453.
Ohta S, Takeuchi M, Deguchi M et al. (2001). "A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway". Biochem. J. 350 Pt 2: 395–404. PMC 1221266. PMID 10947953. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221266.
Ligos JM, de Lera TL, Hinderlich S et al. (2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". J. Biol. Chem. 277 (8): 6333–6343. doi:10.1074/jbc.M105766200. PMID 11741987.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
Guinea B, Ligos JM, Laín de Lera T et al. (2006). "Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation". Exp. Cell Res. 312 (2): 135–144. doi:10.1016/j.yexcr.2005.10.010. PMID 16310770.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

PDB gallery

2buj: CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16 IN COMPLEX WITH STAUROSPORINE

STK16

Interactions

References

Further reading