STAP1
Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.[1][2][3]
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.[3]
Interactions
STAP1 has been shown to interact with C19orf2.[4]
References
- ^ Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H (Nov 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proc Natl Acad Sci U S A 96 (21): 11976–81. doi:10.1073/pnas.96.21.11976. PMC 18397. PMID 10518561. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18397.
- ^ Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M (Mar 2000). "Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains". Biochem Biophys Res Commun 268 (3): 697–703. doi:10.1006/bbrc.2000.2223. PMID 10679268.
- ^ a b "Entrez Gene: BRDG1 BCR downstream signaling 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26228.
- ^ Gstaiger, Matthias; Luke Brian, Hess Daniel, Oakeley Edward J, Wirbelauer Christiane, Blondel Marc, Vigneron Marc, Peter Matthias, Krek Wilhelm (Nov. 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science (United States) 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539.
Further reading
- Kurosaki T (1999). "Genetic analysis of B cell antigen receptor signaling.". Annu. Rev. Immunol. 17 (1): 555–92. doi:10.1146/annurev.immunol.17.1.555. PMID 10358768.
- Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
- Yokohari K, Yamashita Y, Okada S, et al. (2002). "Isoform-dependent interaction of BRDG1 with Tec kinase.". Biochem. Biophys. Res. Commun. 289 (2): 414–20. doi:10.1006/bbrc.2001.6008. PMID 11716489.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Minoguchi M, Minoguchi S, Aki D, et al. (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.". J. Biol. Chem. 278 (13): 11182–9. doi:10.1074/jbc.M211230200. PMID 12540842.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
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PDB gallery
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1x1f: Solution structure of the PH domain of human Docking protein BRDG1
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