STAG1
Cohesin subunit SA-1 is a protein that in humans is encoded by the STAG1 gene.[1][2]
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.[2]
Interactions
STAG1 has been shown to interact with STAG2.[3]
References
- ^ Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, Gonzalez de Buitrago G, Aracil M, Marquez G, Barbero JL, Zipori D (Oct 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
- ^ a b "Entrez Gene: STAG1 stromal antigen 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10274.
- ^ Sumara, I; Vorlaufer E, Gieffers C, Peters B H, Peters J M (Nov. 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. (UNITED STATES) 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169443.
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Losada A, Yokochi T, Hirano T (2006). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.". J. Cell. Sci. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Anazawa Y, Arakawa H, Nakagawa H, Nakamura Y (2004). "Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway.". Oncogene 23 (46): 7621–7. doi:10.1038/sj.onc.1207270. PMID 15361841.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Prieto I, Pezzi N, Buesa JM, et al. (2003). "STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.". EMBO Rep. 3 (6): 543–50. doi:10.1093/embo-reports/kvf108. PMC 1084142. PMID 12034751. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1084142.
- Gregson HC, Schmiesing JA, Kim JS, et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly.". J. Biol. Chem. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.
- Sumara I, Vorlaufer E, Gieffers C, et al. (2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase.". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169443.