SPRY4
Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.[1][2]
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[supplied by OMIM][2]
Interactions
SPRY4 has been shown to interact with TESK1.[3]
References
- ^ Katoh Y, Katoh M (Feb 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". Int J Mol Med 17 (3): 529–32. PMID 16465403.
- ^ a b "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81848.
- ^ Leeksma, Onno C; Van Achterberg Tanja A E, Tsumura Yoshikazu, Toshima Jiro, Eldering Eric, Kroes Wilma G M, Mellink Clemens, Spaargaren Marcel, Mizuno Kensaku, Pannekoek Hans, de Vries Carlie J M (May. 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. (Germany) 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. ISSN 0014-2956. PMID 12027893.
Further reading
- Zaharieva I, Georgieva L, Nikolov I, et al. (2008). "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping.". BMC psychiatry 8: 11. doi:10.1186/1471-244X-8-11. PMC 2268687. PMID 18298822. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2268687.
- Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1.". J. Biol. Chem. 281 (39): 29201–2912. doi:10.1074/jbc.M603921200. PMID 16877379.
- Wang J, Thompson B, Ren C, et al. (2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.". Prostate 66 (6): 613–24. doi:10.1002/pros.20353. PMID 16388505.
- Ding W, Bellusci S, Shi W, Warburton D (2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis.". Am. J. Physiol. Lung Cell Mol. Physiol. 287 (1): L52–9. doi:10.1152/ajplung.00430.2003. PMID 14977631.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sasaki A, Taketomi T, Kato R, et al. (2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.". Nat. Cell Biol. 5 (5): 427–32. doi:10.1038/ncb978. PMID 12717443.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Leeksma OC, Van Achterberg TA, Tsumura Y, et al. (2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1.". Eur. J. Biochem. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.