SPRY1

Sprouty homolog 1, antagonist of FGF signaling (Drosophila)

Identifiers

SPRY1; hSPRY1

External IDs

OMIM: 602465 MGI: 1345139 HomoloGene: 4266 GeneCards: SPRY1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• cytoplasm • cytosol • plasma membrane • lamellipodium
Biological process	• metanephros development • ureteric bud development • organ induction • epidermal growth factor receptor signaling pathway • multicellular organismal development • negative regulation of cell proliferation • regulation of signal transduction • negative regulation of Ras GTPase activity • negative regulation of fibroblast growth factor receptor signaling pathway • negative regulation of epidermal growth factor receptor signaling pathway • negative regulation of MAP kinase activity • negative regulation of Ras protein signal transduction • negative regulation of nerve growth factor receptor signaling pathway • negative regulation of ERK1 and ERK2 cascade
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
124.32 – 124.32 Mb

Chr 3:
37.54 – 37.54 Mb

PubMed search

[1]

[2]

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene.^[1]^[2]^[3]

References

^ Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (Feb 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell 92 (2): 253–63. doi:10.1016/S0092-8674(00)80919-8. PMID 9458049.
^ Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I (Jul 2005). "Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation". EMBO Rep 6 (7): 635–41. doi:10.1038/sj.embor.7400453. PMC 1369112. PMID 15962011. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1369112.
^ "Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10252.

Lim J, Wong ES, Ong SH, et al. (2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.". J. Biol. Chem. 275 (42): 32837–45. doi:10.1074/jbc.M002156200. PMID 10887178.
Egan JE, Hall AB, Yatsula BA, Bar-Sagi D (2002). "The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 6041–6. doi:10.1073/pnas.052090899. PMC 122898. PMID 11983899. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122898.
Hanafusa H, Torii S, Yasunaga T, Nishida E (2004). "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.". Nat. Cell Biol. 4 (11): 850–8. doi:10.1038/ncb867. PMID 12402043.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins.". J. Biochem. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
Wang L, Ji C, Wu H, et al. (2004). "Identification and expression analysis of a novel splice variant of human Sprouty1 gene.". Int. J. Mol. Med. 12 (5): 783–7. PMID 14533010.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Anteby EY, Natanson-Yaron S, Greenfield C, et al. (2005). "Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching.". Placenta 26 (6): 476–83. doi:10.1016/j.placenta.2004.08.008. PMID 15950061.
Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1.". J. Biol. Chem. 281 (39): 29201–2912. doi:10.1074/jbc.M603921200. PMID 16877379.
Fritzsche S, Kenzelmann M, Hoffmann MJ, et al. (2007). "Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma.". Endocr. Relat. Cancer 13 (3): 839–49. doi:10.1677/erc.1.01190. PMID 16954433.
Schaaf G, Hamdi M, et al. (2010). "Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene.". Cancer Research 70 (2): 762–71. doi:10.1158/0008-5472.CAN-09-2532. PMID 20068162.
Nathan J Charles, Robert C Huebert, Sangjin Lee, Neeta Adhikari, Sean Polster, James E Rider, Elizabeth Braunlin, Ami Mariash, Maggie Robledo, David Schuweiler and Jennifer L Hall (2010). "Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function.". Mol Cell Biochem 342 (1,2): 57–62. doi:10.1007/s11010-010-0468-8. PMC 2923832. PMID 20461448. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2923832.

SPRY1

See also

References

Further reading