SPOCK2

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

Identifiers

SPOCK2; FLJ97039; testican-2

External IDs

OMIM: 607988 MGI: 1891351 HomoloGene: 8854 GeneCards: SPOCK2 Gene

Gene Ontology
Molecular function	• calcium ion binding • glycosaminoglycan binding • extracellular matrix binding
Cellular component	• extracellular region • proteinaceous extracellular matrix
Biological process	• signal transduction • synapse assembly • positive regulation of cell-substrate adhesion • peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan • extracellular matrix organization • regulation of cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
73.82 – 73.85 Mb

Chr 10:
59.57 – 59.6 Mb

PubMed search

[1]

[2]

Testican-2 is a protein that in humans is encoded by the SPOCK2 gene.^[1]^[2]

Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK2 encodes a member of a novel Ca(2+)-binding proteoglycan family.[supplied by OMIM]^[2]

References

^ Vannahme C, Schubel S, Herud M, Gosling S, Hulsmann H, Paulsson M, Hartmann U, Maurer P (Jul 1999). "Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain". J Neurochem 73 (1): 12–20. doi:10.1046/j.1471-4159.1999.0730012.x. PMID 10386950.
^ ^a ^b "Entrez Gene: SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9806.

Nagase T, Seki N, Ishikawa K et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Nakada M, Miyamori H, Yamashita J, Sato H (2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Res. 63 (12): 3364–9. PMID 12810672.
Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

SPOCK2

References

Further reading