SPC24

SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)

Identifiers

SPC24; FLJ90806; SPBC24

External IDs

OMIM: 609394 MGI: 1914879 HomoloGene: 12166 GeneCards: SPC24 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• condensed chromosome kinetochore • nucleus • chromosome • cytosol • Ndc80 complex
Biological process	• M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • cell division
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000161888

ENSMUSG00000074476

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
11.26 – 11.27 Mb

Chr 9:
21.56 – 21.56 Mb

PubMed search

Kinetochore protein Spc24 is a protein that in humans is encoded by the SPC24 gene.^[1]

References

^ "Entrez Gene: SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147841.

Further reading

Nousiainen M, Silljé HH, Sauer G et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365.
Ahonen LJ, Kallio MJ, Daum JR et al. (2005). "Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Curr. Biol. 15 (12): 1078–89. doi:10.1016/j.cub.2005.05.026. PMID 15964272.
Ciferri C, De Luca J, Monzani S et al. (2005). "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore". J. Biol. Chem. 280 (32): 29088–95. doi:10.1074/jbc.M504070200. PMID 15961401.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Cheeseman IM, Niessen S, Anderson S et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=517519.
McCleland ML, Kallio MJ, Barrett-Wilt GA et al. (2004). "The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment". Curr. Biol. 14 (2): 131–7. doi:10.1016/j.cub.2003.12.058. PMID 14738735.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bharadwaj R, Qi W, Yu H (2004). "Identification of two novel components of the human NDC80 kinetochore complex". J. Biol. Chem. 279 (13): 13076–85. doi:10.1074/jbc.M310224200. PMID 14699129.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.