SOX12

SRY (sex determining region Y)-box 12
Identifiers
Symbols SOX12; SOX22
External IDs OMIM: 601947 MGI: 98360 HomoloGene: 5057 GeneCards: SOX12 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6666 20667
Ensembl ENSG00000177732 ENSMUSG00000051817
UniProt O15370 Q04890
RefSeq (mRNA) NM_006943 NM_011438.2
RefSeq (protein) NP_008874 NP_035568.1
Location (UCSC) Chr 20:
0.31 – 0.31 Mb		 Chr 2:
152.22 – 152.22 Mb
PubMed search [1] [2]

SOX12 is a protein that in humans is encoded by the SOX12 gene.[1][2] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.[3] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.[4]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.[2]

References

  1. ^ Jay P, Sahly I, Goze C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P (Aug 1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet 6 (7): 1069–77. doi:10.1093/hmg/6.7.1069. PMID 9215677. 
  2. ^ a b "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6666. 
  3. ^ Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008). "Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors". Mol. Cell. Biol. 28 (15): 4675–87. doi:10.1128/MCB.00338-08. PMC 2493363. PMID 18505825. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2493363. 
  4. ^ Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V (May 2008). "The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. doi:10.1093/nar/gkn162. PMC 2396431. PMID 18403418. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2396431. 

Further reading