SORBS1

Sorbin and SH3 domain containing 1

PDB rendering based on 2dl3.

Available structures
PDB	2DL3, 2ECZ, 2O2W, 2O31, 2O9S, 2O9V

Identifiers

Symbols

SORBS1; CAP; DKFZp451C066; DKFZp586P1422; FLAF2; FLJ12406; KIAA1296; R85FL; SH3D5; SH3P12; SORB1

External IDs

OMIM: 605264 MGI: 700014 HomoloGene: 83252 GeneCards: SORBS1 Gene

Gene Ontology
Molecular function	• actin binding • SH3/SH2 adaptor activity • SH3/SH2 adaptor activity • insulin receptor binding • protein binding • cytoskeletal protein binding • protein kinase binding
Cellular component	• stress fiber • nucleus • nucleolus • cytoplasm • centrosome • cytosol • cytosol • cytoskeleton • plasma membrane • insulin receptor complex • cell-cell adherens junction • zonula adherens • cell-substrate adherens junction • focal adhesion • cell junction • membrane raft
Biological process	• transport • muscle contraction • cell-matrix adhesion • insulin receptor signaling pathway • glucose transport • cellular response to insulin stimulus • stress fiber assembly • positive regulation of glycogen biosynthetic process • positive regulation of glucose import • positive regulation of lipid biosynthetic process • focal adhesion assembly • positive regulation of establishment of protein localization in plasma membrane
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
97.07 – 97.32 Mb

Chr 19:
40.37 – 40.59 Mb

PubMed search

[1]

[2]

Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SORBS1 gene.^[1]^[2]^[3]

Interactions

SORBS1 has been shown to interact with FLOT1,^[2]^[4]^[5] Vinculin,^[1] INSM1,^[6] MLLT4,^[1] Cbl gene^[4]^[7] and INPPL1.^[7]

References

^ ^a ^b ^c Mandai K, Nakanishi H, Satoh A, Takahashi K, Satoh K, Nishioka H, Mizoguchi A, Takai Y (Jun 1999). "Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions". J Cell Biol 144 (5): 1001–17. doi:10.1083/jcb.144.5.1001. PMC 2148189. PMID 10085297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2148189.
^ ^a ^b Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (Oct 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport". Nature 407 (6801): 202–7. doi:10.1038/35025089. PMID 11001060.
^ "Entrez Gene: SORBS1 sorbin and SH3 domain containing 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10580.
^ ^a ^b Haglund, Kaisa; Ivankovic-Dikic Inga, Shimokawa Noriaki, Kruh Gary D, Dikic Ivan (May. 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell. Sci. (England) 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. ISSN 0021-9533. PMID 15128873.
^ Kimura, A; Baumann C A, Chiang S H, Saltiel A R (Jul. 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (16): 9098–103. doi:10.1073/pnas.151252898. ISSN 0027-8424. PMC 55379. PMID 11481476. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55379.
^ Xie, Jingping; Cai Tao, Zhang Honglai, Lan Michael S, Notkins Abner Louis (Jul. 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics (United States) 80 (1): 54–61. doi:10.1006/geno.2002.6800. ISSN 0888-7543. PMC 1237014. PMID 12079283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1237014.
^ ^a ^b Vandenbroere, Isabelle; Paternotte Nathalie, Dumont Jacques E, Erneux Christophe, Pirson Isabelle (Jan. 2003). "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2". Biochem. Biophys. Res. Commun. (United States) 300 (2): 494–500. doi:10.1016/S0006-291X(02)02894-2. ISSN 0006-291X. PMID 12504111.

Kioka N (2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku 74 (11): 1356–60. PMID 12510380.
Ribon V, Herrera R, Kay BK, Saltiel AR (1998). "A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions.". J. Biol. Chem. 273 (7): 4073–80. doi:10.1074/jbc.273.7.4073. PMID 9461600.
Asakura T, Nakanishi H, Sakisaka T, et al. (2000). "Similar and differential behaviour between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells.". Genes Cells 4 (10): 573–81. doi:10.1046/j.1365-2443.1999.00283.x. PMID 10583506.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Lebre AS, Jamot L, Takahashi J, et al. (2001). "Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions.". Hum. Mol. Genet. 10 (11): 1201–13. doi:10.1093/hmg/10.11.1201. PMID 11371513.
Lin WH, Huang CJ, Liu MW, et al. (2001). "Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.". Genomics 74 (1): 12–20. doi:10.1006/geno.2001.6541. PMID 11374898.
Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts.". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55379.
Lin WH, Chiu KC, Chang HM, et al. (2002). "Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes.". Hum. Mol. Genet. 10 (17): 1753–60. doi:10.1093/hmg/10.17.1753. PMID 11532984.
Cowan CA, Henkemeyer M (2001). "The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.". Nature 413 (6852): 174–9. doi:10.1038/35093123. PMID 11557983.
Liu J, Kimura A, Baumann CA, Saltiel AR (2002). "APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.". Mol. Cell. Biol. 22 (11): 3599–609. doi:10.1128/MCB.22.11.3599-3609.2002. PMC 133825. PMID 11997497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133825.
Xie J, Cai T, Zhang H, et al. (2003). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.". Genomics 80 (1): 54–61. doi:10.1006/geno.2002.6800. PMC 1237014. PMID 12079283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1237014.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Vandenbroere I, Paternotte N, Dumont JE, et al. (2003). "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.". Biochem. Biophys. Res. Commun. 300 (2): 494–500. doi:10.1016/S0006-291X(02)02894-2. PMID 12504111.
Yang WS, Lee WJ, Huang KC, et al. (2003). "mRNA levels of the insulin-signaling molecule SORBS1 in the adipose depots of nondiabetic women.". Obes. Res. 11 (4): 586–90. doi:10.1038/oby.2003.82. PMID 12690089.

PDB gallery

2dl3: Solution structure of the first SH3 domain of human sorbin and Sh3 domain-containing protein 1

SORBS1

Interactions

References

Further reading