SOCS5

Suppressor of cytokine signaling 5

Identifiers

SOCS5; CIS6; CISH6; Cish5; KIAA0671; SOCS-5

External IDs

OMIM: 607094 MGI: 2385459 HomoloGene: 10495 GeneCards: SOCS5 Gene

Gene Ontology
Molecular function	• epidermal growth factor receptor binding
Cellular component	• cytoplasm
Biological process	• epidermal growth factor receptor signaling pathway • negative regulation of signal transduction • cell growth • cytokine-mediated signaling pathway • intracellular signal transduction • regulation of growth • positive regulation of T-helper 1 cell differentiation • negative regulation of T-helper 2 cell differentiation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
46.93 – 46.99 Mb

Chr 17:
87.51 – 87.54 Mb

PubMed search

[1]

[2]

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.^[1]^[2]^[3]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.^[3]

References

^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
^ ^a ^b "Entrez Gene: SOCS5 suppressor of cytokine signaling 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9655.

Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. doi:10.1002/jnr.10145. PMID 11835308.
Krebs DL, Hilton DJ (2001). "SOCS proteins: negative regulators of cytokine signaling". Stem Cells 19 (5): 378–87. doi:10.1634/stemcells.19-5-378. PMID 11553846.
Ozaki A, Seki Y, Fukushima A, Kubo M (2005). "The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model". J. Immunol. 175 (8): 5489–97. PMID 16210657.
Kario E, Marmor MD, Adamsky K, et al. (2005). "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling". J. Biol. Chem. 280 (8): 7038–48. doi:10.1074/jbc.M408575200. PMID 15590694.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Bayle J, Letard S, Frank R, et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling". J. Biol. Chem. 279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID 14707129.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Seki Y, Hayashi K, Matsumoto A, et al. (2002). "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13003–8. doi:10.1073/pnas.202477099. PMC 130576. PMID 12242343. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=130576.
Magrangeas F, Apiou F, Denis S, et al. (2000). "Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 78–81. doi:10.1159/000015490. PMID 10773671.
Hilton DJ, Richardson RT, Alexander WS, et al. (1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. doi:10.1073/pnas.95.1.114. PMC 18144. PMID 9419338. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18144.

JAK-STAT signaling pathway

Ligand

Cytokine

Cytokine receptor

Type I cytokine receptor · Type II cytokine receptor

Janus kinase

JAK1 · JAK2 · JAK3 · TYK2

Adaptor proteins

STAT	STAT1 · STAT2 · STAT3 · STAT4 · STAT5 · STAT6

PIAS	PIAS1 · PIAS2 · PIAS3 · PIAS4

SOCS	1, 2, 3, 4, 5, 6, 7

IRF	IRF1 · IRF2 · IRF3 · IRF4 · IRF5 · IRF6 · IRF7 · IRF8

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

SOCS5

References

Further reading