SOCS2

Suppressor of cytokine signaling 2

PDB rendering based on 2c9w.
Identifiers
Symbols SOCS2; CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
External IDs OMIM: 605117 MGI: 1201787 HomoloGene: 2880 GeneCards: SOCS2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8835 216233
Ensembl ENSG00000120833 ENSMUSG00000020027
UniProt O14508 Q548Q7
RefSeq (mRNA) NM_003877 NM_007706
RefSeq (protein) NP_003868 NP_031732
Location (UCSC) Chr 12:
93.96 – 93.97 Mb		 Chr 10:
94.85 – 94.88 Mb
PubMed search [1] [2]

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.[1][2][3][2][1]

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.[4] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.[5][3]

Contents

Interactions

SOCS2 has been shown to interact with Insulin-like growth factor 1 receptor[4] and Erythropoietin receptor.[6]

References

  1. ^ a b Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848. 
  2. ^ a b Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (Sep 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833. 
  3. ^ a b "Entrez Gene: SOCS2 suppressor of cytokine signaling 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8835. 
  4. ^ a b Dey BR, Spence SL, Nissley P, Furlanetto RW (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029. 
  5. ^ Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, Davey HW, Nicola NA, Hilton DJ, Alexander WS (June 2002). "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)". Mol. Endocrinol. 16 (6): 1394–406. doi:10.1210/me.16.6.1394. PMID 12040024. 
  6. ^ Eyckerman, S; Verhee A, der Heyden J V, Lemmens I, Ostade X V, Vandekerckhove J, Tavernier J (Dec. 2001). "Design and application of a cytokine-receptor-based interaction trap". Nat. Cell Biol. (England) 3 (12): 1114–9. doi:10.1038/ncb1201-1114. ISSN 1465-7392. PMID 11781573. 

Further reading

External links

Ligand
Cytokine receptor
Janus kinase
JAK1 · JAK2 · JAK3 · TYK2
Adaptor proteins
STAT1 · STAT2 · STAT3 · STAT4 · STAT5 · STAT6
PIAS1 · PIAS2 · PIAS3 · PIAS4
1, 2, 3, 4, 5, 6, 7
IRF1 · IRF2 · IRF3 · IRF4 · IRF5 · IRF6 · IRF7 · IRF8
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)