SNX27

Sorting nexin family member 27

Identifiers

SNX27; KIAA0488; MGC126871; MGC126873; MGC20471; MRT1; MY014

External IDs

OMIM: 611541 MGI: 1923992 HomoloGene: 12797 GeneCards: SNX27 Gene

Gene Ontology
Molecular function	• protein binding • phosphatidylinositol binding
Cellular component	• cytoplasm • early endosome • cytosol
Biological process	• cell communication • signal transduction • protein transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
151.58 – 151.67 Mb

Chr 3:
94.3 – 94.39 Mb

PubMed search

[1]

[2]

Sorting nexin family member 27, also known as SNX27, is a human gene.^[1]

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.^[1]

References

^ ^a ^b "Entrez Gene: SNX27 sorting nexin family member 27". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81609.

Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Seki N, Ohira M, Nagase T et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Teasdale RD, Loci D, Houghton F et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222026.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Williams R, Schlüter T, Roberts MS et al. (2005). "Sorting Nexin 17 Accelerates Internalization Yet Retards Degradation of P-selectin". Mol. Biol. Cell 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMC 452567. PMID 15121882. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452567.
Joubert L, Hanson B, Barthet G et al. (2005). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". J. Cell. Sci. 117 (Pt 22): 5367–79. doi:10.1242/jcs.01379. PMID 15466885.
Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Rincón E, Santos T, Avila-Flores A et al. (2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling". Mol. Cell Proteomics 6 (6): 1073–87. doi:10.1074/mcp.M700047-MCP200. PMID 17351151.
MacNeil AJ, Mansour M, Pohajdak B (2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochem. Biophys. Res. Commun. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.

Sorting nexins

SNX-BAR	SNX1 · SNX2 · SNX4 · SNX5 · SNX6 · SNX7 · SNX8 · SNX9 · SNX18 · SNX30 · SNX32 · SNX33

SNX-PX	SNX3 · SNX10 · SNX11 · SNX12 · SNX16 · SNX20 · SNX21 · SNX22 · SNX24 · SNX29

SNX-Other	SNX13 · SNX14 · SNX15 · SNX17 · SNX19 · SNX23 · SNX25 · SNX26 · SNX27 · SNX28 · SNX31

Related articles	PX domain · BAR domain · Retromer

B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

SNX27

References

Further reading