SNX2

Sorting nexin 2

Identifiers

SNX2; MGC5204; TRG-9

External IDs

OMIM: 605929 MGI: 1915054 HomoloGene: 2332 GeneCards: SNX2 Gene

Gene Ontology
Molecular function	• protein binding • lipid binding • protein transporter activity • phosphatidylinositol binding
Cellular component	• cytoplasm • endosome • endosome membrane • membrane • early endosome membrane
Biological process	• intracellular protein transport • endocytosis • cell communication
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
122.11 – 122.17 Mb

Chr 18:
53.34 – 53.38 Mb

PubMed search

[1]

[2]

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.^[1]^[2]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.^[2]

Interactions

SNX2 has been shown to interact with FNBP1.^[3]^[4]

References

^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol 18 (12): 7278–87. PMC 109309. PMID 9819414. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109309.
^ ^a ^b "Entrez Gene: SNX2 sorting nexin 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6643.
^ Fuchs, U; Rehkamp G F, Slany R, Follo M, Borkhardt A (Nov. 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Lett. (Netherlands) 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. ISSN 0014-5793. PMID 14596906.
^ Fuchs, U; Rehkamp G, Haas O A, Slany R, Kōnig M, Bojesen S, Bohle R M, Damm-Welk C, Ludwig W D, Harbott J, Borkhardt A (Jul. 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (15): 8756–61. doi:10.1073/pnas.121433898. ISSN 0027-8424. PMC 37508. PMID 11438682. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=37508.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Haft CR, de la Luz Sierra M, Bafford R, et al. (2001). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes". Mol. Biol. Cell 11 (12): 4105–16. PMC 15060. PMID 11102511. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15060.
Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
Fuchs U, Rehkamp G, Haas OA, et al. (2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=37508.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222026.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Fuchs U, Rehkamp GF, Slany R, et al. (2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Lett. 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gullapalli A, Garrett TA, Paing MM, et al. (2005). "A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking". Mol. Biol. Cell 15 (5): 2143–55. doi:10.1091/mbc.E03-09-0711. PMC 404011. PMID 14978220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=404011.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Schaaf CP, Benzing J, Schmitt T, et al. (2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB J. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961.
Abdul-Ghani M, Hartman KL, Ngsee JK (2005). "Abstrakt interacts with and regulates the expression of sorting nexin-2". J. Cell. Physiol. 204 (1): 210–8. doi:10.1002/jcp.20285. PMC 2963638. PMID 15690390. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2963638.
Carlton JG, Bujny MV, Peter BJ, et al. (2006). "Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport". J. Cell. Sci. 118 (Pt 19): 4527–39. doi:10.1242/jcs.02568. PMC 1904489. PMID 16179610. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1904489.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Rojas R, Kametaka S, Haft CR, Bonifacino JS (2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Mol. Cell. Biol. 27 (3): 1112–24. doi:10.1128/MCB.00156-06. PMC 1800681. PMID 17101778. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1800681.
Skånland SS, Wälchli S, Utskarpen A, et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. PMID 17319803.

Sorting nexins

SNX-BAR	SNX1 · SNX2 · SNX4 · SNX5 · SNX6 · SNX7 · SNX8 · SNX9 · SNX18 · SNX30 · SNX32 · SNX33

SNX-PX	SNX3 · SNX10 · SNX11 · SNX12 · SNX16 · SNX20 · SNX21 · SNX22 · SNX24 · SNX29

SNX-Other	SNX13 · SNX14 · SNX15 · SNX17 · SNX19 · SNX23 · SNX25 · SNX26 · SNX27 · SNX28 · SNX31

Related articles	PX domain · BAR domain · Retromer

B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

SNX2

Interactions

References

Further reading