| Sorting nexin 13 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SNX13; KIAA0713; RGS-PX1 | ||||||||||||
| External IDs | OMIM: 606589 MGI: 2661416 HomoloGene: 41011 GeneCards: SNX13 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23161 | 217463 | |||||||||||
| Ensembl | ENSG00000071189 | ENSMUSG00000020590 | |||||||||||
| UniProt | Q9Y5W8 | Q3TCG6 | |||||||||||
| RefSeq (mRNA) | NM_015132 | NM_001014973.2 | |||||||||||
| RefSeq (protein) | NP_055947 | NP_001014973.2 | |||||||||||
| Location (UCSC) | Chr 7: 17.83 – 17.98 Mb |
Chr 12: 35.73 – 35.83 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.[1][2][3]
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.[3]
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