Sorting nexin 1 | |||||||||||||
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PDB rendering based on 2i4k. |
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Identifiers | |||||||||||||
Symbols | SNX1; HsT17379; MGC8664; SNX1A; Vps5 | ||||||||||||
External IDs | OMIM: 601272 MGI: 1928395 HomoloGene: 99716 GeneCards: SNX1 Gene | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 6642 | 56440 | |||||||||||
Ensembl | ENSG00000028528 | ENSMUSG00000032382 | |||||||||||
UniProt | Q13596 | Q9WV80 | |||||||||||
RefSeq (mRNA) | NM_003099.3 | NM_019727.2 | |||||||||||
RefSeq (protein) | NP_003090.2 | NP_062701.2 | |||||||||||
Location (UCSC) | Chr 15: 64.39 – 64.44 Mb |
Chr 9: 65.94 – 65.97 Mb |
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PubMed search | [1] | [2] |
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin.[1] SNX1 is a component of the retromer complex.[2][3]
Contents |
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.[4]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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