SNW1
SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.[1][2][3]
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.[3]
Interactions
SNW1 has been shown to interact with Histone deacetylase 2,[4] SKI protein,[5][6][7] Retinoblastoma protein,[8] PABPN1,[9] CIR,[4] RBPJ,[4][10] Nuclear receptor coactivator 1,[11] Nuclear receptor co-repressor 2,[4][10] Calcitriol receptor,[2][11] Mothers against decapentaplegic homolog 3,[7] NOTCH1[12][10] and Mothers against decapentaplegic homolog 2.[7]
References
- ^ Folk P, Puta F, Krpejsova L, Blahuskova A, Markos A, Rabino M, Dottin RP (Jan 1997). "The homolog of chromatin binding protein Bx42 identified in Dictyostelium". Gene 181 (1–2): 229–31. doi:10.1016/S0378-1119(96)00483-0. PMID 8973337.
- ^ a b Baudino TA, Kraichely DM, Jefcoat SC Jr, Winchester SK, Partridge NC, MacDonald PN (Aug 1998). "Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription". J Biol Chem 273 (26): 16434–41. doi:10.1074/jbc.273.26.16434. PMID 9632709.
- ^ a b "Entrez Gene: SNW1 SNW domain containing 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22938.
- ^ a b c d Zhou, S; Fujimuro M, Hsieh J J, Chen L, Hayward S D (Feb. 2000). "A Role for SKIP in EBNA2 Activation of CBF1-Repressed Promoters". J. Virol. (UNITED STATES) 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. ISSN 0022-538X. PMC 111672. PMID 10644367. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=111672.
- ^ Prathapam, T; Kühne C, Hayman M, Banks L (Sep. 2001). "Ski interacts with the evolutionarily conserved SNW domain of Skip". Nucleic Acids Res. (England) 29 (17): 3469–76. doi:10.1093/nar/29.17.3469. PMC 55893. PMID 11522815. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55893.
- ^ Dahl, R; Wani B, Hayman M J (Mar. 1998). "The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42". Oncogene (ENGLAND) 16 (12): 1579–86. doi:10.1038/sj.onc.1201687. ISSN 0950-9232. PMID 9569025.
- ^ a b c Leong, G M; Subramaniam N, Figueroa J, Flanagan J L, Hayman M J, Eisman J A, Kouzmenko A P (May. 2001). "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". J. Biol. Chem. (United States) 276 (21): 18243–8. doi:10.1074/jbc.M010815200. ISSN 0021-9258. PMID 11278756.
- ^ Prathapam, Tulasiram; Kühne Christian, Banks Lawrence (Dec. 2002). "Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity". Nucleic Acids Res. (England) 30 (23): 5261–8. doi:10.1093/nar/gkf658. PMC 137971. PMID 12466551. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137971.
- ^ Kim, Y J; Noguchi S, Hayashi Y K, Tsukahara T, Shimizu T, Arahata K (May. 2001). "The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression". Hum. Mol. Genet. (England) 10 (11): 1129–39. doi:10.1093/hmg/10.11.1129. ISSN 0964-6906. PMID 11371506.
- ^ a b c Zhou, S; Fujimuro M, Hsieh J J, Chen L, Miyamoto A, Weinmaster G, Hayward S D (Apr. 2000). "SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function". Mol. Cell. Biol. (UNITED STATES) 20 (7): 2400–10. doi:10.1128/MCB.20.7.2400-2410.2000. ISSN 0270-7306. PMC 85419. PMID 10713164. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85419.
- ^ a b Zhang, C; Baudino T A, Dowd D R, Tokumaru H, Wang W, MacDonald P N (Nov. 2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". J. Biol. Chem. (United States) 276 (44): 40614–20. doi:10.1074/jbc.M106263200. ISSN 0021-9258. PMID 11514567.
- ^ Beatus, P; Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun. 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mech. Dev. (Ireland) 104 (1–2): 3–20. doi:10.1016/S0925-4773(01)00373-2. ISSN 0925-4773. PMID 11404076.
Further reading
- Dahl R, Wani B, Hayman MJ (1998). "The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42". Oncogene 16 (12): 1579–86. doi:10.1038/sj.onc.1201687. PMID 9569025.
- Zhou S, Fujimuro M, Hsieh JJ, et al. (2000). "A Role for SKIP in EBNA2 Activation of CBF1-Repressed Promoters". J. Virol. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC 111672. PMID 10644367. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=111672.
- Zhou S, Fujimuro M, Hsieh JJ, et al. (2000). "SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function". Mol. Cell. Biol. 20 (7): 2400–10. doi:10.1128/MCB.20.7.2400-2410.2000. PMC 85419. PMID 10713164. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85419.
- Leong GM, Subramaniam N, Figueroa J, et al. (2001). "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". J. Biol. Chem. 276 (21): 18243–8. doi:10.1074/jbc.M010815200. PMID 11278756.
- Kim YJ, Noguchi S, Hayashi YK, et al. (2001). "The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression". Hum. Mol. Genet. 10 (11): 1129–39. doi:10.1093/hmg/10.11.1129. PMID 11371506.
- Beatus P, Lundkvist J, Oberg C, et al. (2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mech. Dev. 104 (1–2): 3–20. doi:10.1016/S0925-4773(01)00373-2. PMID 11404076.
- Zhou S, Hayward SD (2001). "Nuclear Localization of CBF1 Is Regulated by Interactions with the SMRT Corepressor Complex". Mol. Cell. Biol. 21 (18): 6222–32. doi:10.1128/MCB.21.18.6222-6232.2001. PMC 87339. PMID 11509665. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87339.
- Zhang C, Baudino TA, Dowd DR, et al. (2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". J. Biol. Chem. 276 (44): 40614–20. doi:10.1074/jbc.M106263200. PMID 11514567.
- Prathapam T, Kühne C, Hayman M, Banks L (2001). "Ski interacts with the evolutionarily conserved SNW domain of Skip". Nucleic Acids Res. 29 (17): 3469–76. doi:10.1093/nar/29.17.3469. PMC 55893. PMID 11522815. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55893.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370266.
- Wardell SE, Boonyaratanakornkit V, Adelman JS, et al. (2002). "Jun Dimerization Protein 2 Functions as a Progesterone Receptor N-Terminal Domain Coactivator". Mol. Cell. Biol. 22 (15): 5451–66. doi:10.1128/MCB.22.15.5451-5466.2002. PMC 133955. PMID 12101239. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133955.
- Prathapam T, Kühne C, Banks L (2002). "Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity". Nucleic Acids Res. 30 (23): 5261–8. doi:10.1093/nar/gkf658. PMC 137971. PMID 12466551. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137971.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
- Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
- Barry JB, Leong GM, Church WB, et al. (2003). "Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues". J. Biol. Chem. 278 (10): 8224–8. doi:10.1074/jbc.C200712200. PMID 12529369.
- Zhang C, Dowd DR, Staal A, et al. (2003). "Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing". J. Biol. Chem. 278 (37): 35325–36. doi:10.1074/jbc.M305191200. PMID 12840015.
- Leong GM, Subramaniam N, Issa LL, et al. (2004). "Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300". Biochem. Biophys. Res. Commun. 315 (4): 1070–6. doi:10.1016/j.bbrc.2004.02.004. PMID 14985122.