SNRPA1

Small nuclear ribonucleoprotein polypeptide A'

PDB rendering based on 1a9n.

Available structures
PDB	1a9n

Identifiers

Symbols

SNRPA1;

External IDs

OMIM: 603521 MGI: 1916231 HomoloGene: 2325 GeneCards: SNRPA1 Gene

Gene Ontology
Molecular function	• RNA binding • protein binding
Cellular component	• nucleus • nucleoplasm • spliceosomal complex • U2 snRNP • small nuclear ribonucleoprotein complex • catalytic step 2 spliceosome
Biological process	• nuclear mRNA splicing, via spliceosome • nuclear mRNA splicing, via spliceosome • RNA splicing • gene expression
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
101.82 – 101.84 Mb

Chr 7:
73.21 – 73.22 Mb

PubMed search

[1]

[2]

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.^[1]^[2]

Interactions

SNRPA1 has been shown to interact with CDC5L.^[3]

References

^ Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (May 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Res 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC 317531. PMID 2928112. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=317531.
^ "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6627.
^ Ajuh, P; Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (Dec. 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305846.

Ohno M, Kataoka N, Shimura Y (1991). "A nuclear cap binding protein from HeLa cells.". Nucleic Acids Res. 18 (23): 6989–95. doi:10.1093/nar/18.23.6989. PMC 332760. PMID 2148205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=332760.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kjems J, Sharp PA (1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly". J. Virol. 67 (8): 4769–76. PMC 237863. PMID 8331728. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=237863.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Blencowe BJ, Issner R, Nickerson JA, Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316672.
Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature 394 (6694): 645–50. doi:10.1038/29234. PMID 9716128.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26846.
Lundin M, Mikkelsen B, Gudim M, Syed M (2000). "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed". Marine biotechnology 2 (2): 204–211. doi:10.1007/s101269900015. PMID 10811961.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370266.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

PDB gallery

1a9n: CRYSTAL STRUCTURE OF THE SPLICEOSOMAL U2B-U2A' PROTEIN COMPLEX BOUND TO A FRAGMENT OF U2 SMALL NUCLEAR RNA

RNA-binding protein: Ribonucleoproteins

snRNP	A · A1 · B · B2 · C · D1 · D2 · D3 · E · F · G · N 70K/U1 spliceosomal RNA SNRNP200

hnRNP	A0 · C · L · R

Other transcription	Telomerase

Translation	Ribosome

Vault ribonucleoprotein particles	Major vault protein

Other	Signal recognition particle

B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

SNRPA1

Interactions

References

Further reading